Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress
dc.contributor.author | Allaw, Mohamad | |
dc.contributor.author | Manconi, Maria | |
dc.contributor.author | Aroffu, Matteo | |
dc.contributor.author | Marongiu, Francesca | |
dc.contributor.author | Porceddu, Marco | |
dc.contributor.author | Bacchetta, Gianluigi | |
dc.contributor.author | Usach, Iris | |
dc.contributor.author | Rached, Rita Abi | |
dc.contributor.author | Rajha, Hiba N. | |
dc.contributor.author | Maroun, Richard G. | |
dc.contributor.author | Pedraz Muñoz, José Luis | |
dc.contributor.author | López Méndez, Tania Belén | |
dc.contributor.author | Fadda, Anna Maria | |
dc.contributor.author | Manca, Maria Letizia | |
dc.date.accessioned | 2020-12-11T09:22:37Z | |
dc.date.available | 2020-12-11T09:22:37Z | |
dc.date.issued | 2020-10-23 | |
dc.identifier.citation | Pharmaceutics 12(11) : (2020) // Article ID 1010 | es_ES |
dc.identifier.issn | 1999-4923 | |
dc.identifier.uri | http://hdl.handle.net/10810/48942 | |
dc.description.abstract | An extract of Hypericum scruglii, an endangered endemic plant of Sardinia (Italy), was prepared and characterized. It was loaded in special phospholipid vesicles, glycerosomes, which were modified by adding maltodextrin (glucidex) and a polymer (gelatin or hyaluronan). The corresponding liposomes were also prepared and used as reference. The vesicles disclosed suitable physicochemical features for skin delivery. Indeed, their mean diameter ranged from 120 to 160 nm, they were homogeneously dispersed (polydispersity index ≤ 0.30), and their zeta potential was highly negative (~−45 mV). The vesicle dispersions maintained unchanged characteristics during 60 days of storage, were highly biocompatible, and were able to protect keratinocytes against damages due to oxidative stress induced by treating them with hydrogen peroxide. Vesicles were also capable of promoting cell proliferation and migration in vitro by means of a scratch wound assay. The results confirmed the fruitful delivery of the extract of H. scruglii in glycerosomes modified with glucidex and gelatin and their promising ability for skin protection and treatment. | es_ES |
dc.description.sponsorship | This research was supported by the Italian Ministry of Education, University and Scientific Research (MIUR), Grant No. PON A.A. 2017/2018, Molecole bioattive naturali veicolate in vescicole lamellari per la cura delle lesioni cutanee (cod = DOT1304004). This research was supported by FSC 2014-2020—Patto per lo Sviluppo della Regione Sardegna (RASSR14371). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | hypericaceae | es_ES |
dc.subject | phospholipid vesicles | es_ES |
dc.subject | glycerosomes | es_ES |
dc.subject | gelatin | es_ES |
dc.subject | hyaluronan | es_ES |
dc.subject | oxidative stress | es_ES |
dc.subject | scratch assay | es_ES |
dc.subject | keratinocyte uptake | es_ES |
dc.title | Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-11-26T14:10:14Z | |
dc.rights.holder | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/12/11/1010/htm | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics12111010 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | |
dc.departamentoeu | Farmazia eta elikagaien zientziak |
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Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).