Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
dc.contributor.author | Martín Suárez, Soraya | |
dc.contributor.author | Abiega Etxabe, Oihane | |
dc.contributor.author | Ricobaraza, Ana | |
dc.contributor.author | Hernández Alcoceba, Rubén | |
dc.contributor.author | Encinas Pérez, Juan Manuel | |
dc.date.accessioned | 2020-12-22T12:30:05Z | |
dc.date.available | 2020-12-22T12:30:05Z | |
dc.date.issued | 2020-07-21 | |
dc.identifier.citation | Frontiers in Cell and Developmental Biology 8 : (2020) // Article ID 654 | es_ES |
dc.identifier.issn | 2296-634X | |
dc.identifier.uri | http://hdl.handle.net/10810/49222 | |
dc.description.abstract | Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe alterations have been found in samples from epilepsy patients and in the hippocampal neurogenic niche in mouse models of epilepsy. Reactive-like and gliogenic NSCs plus aberrant newborn neurons with altered migration, morphology, and functional properties are induced by seizures in experimental models of temporal lobe epilepsy. Hippocampal neurogenesis participates in memory and learning and in the control of anxiety and stress. It has been therefore hypothesized that part of the cognitive symptoms associated with epilepsy could be promoted by impaired hippocampal neurogenesis. We here analyze for the first time the alterations of the neurogenic niche in a novel mouse model of Dravet syndrome (DS), a genetic encephalopathy with severe epilepsy in infancy and multiple neurological comorbidities. Scn1a(WT/A1783V)mice, hereafter referred to as DS, carrying a heterozygous and clinically relevant SCN1A mutation (A1783V) recapitulate the disease at the genetic and phenotypic levels. We demonstrate that in the neurogenic niche of young adult DS mice there are fewer NSCs, they have impaired cell division and bear reactive-like morphology. In addition, there is significant aberrant neurogenesis. Newborn immature neurons migrate abnormally, and several morphological features are drastically changed. Thus, this study shows for the first time important modifications in hippocampal neurogenesis in DS and opens venues for further research on this topic. | es_ES |
dc.description.sponsorship | This work was supported by Spanish Ministry of Economy and Competitiveness (MINECO) Grant/Award Numbers SAF-2015-70866-R (with FEDER Funds) and RyC-212-11137 to JE and RTI2018-097730-B-I00/MCI/AEI/FEDER, UE, and AC17/00029 (ISCIII)/FEDER to RH-A. SM-S received a Fundacion Tatiana predoctoral fellowship. OA is the recipient of a Basque Government postdoctoral fellowship. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF-2015-70866-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RyC-212-11137 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RTI2018-097730-B-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | neural stem cells | es_ES |
dc.subject | aberrant neurogenesis | es_ES |
dc.subject | gliosis | es_ES |
dc.subject | Dravet syndrome | es_ES |
dc.subject | SCN1A | es_ES |
dc.subject | severe myoclonic epilepsy | es_ES |
dc.subject | dentate granule cells | es_ES |
dc.subject | adult neurogenesis | es_ES |
dc.subject | pattern separation | es_ES |
dc.subject | neurons | es_ES |
dc.subject | gyrus | es_ES |
dc.subject | seizures | es_ES |
dc.subject | differentiation | es_ES |
dc.subject | reorganization | es_ES |
dc.title | Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2020 Martín-Suárez, Abiega, Ricobaraza, Hernandez-Alcoceba and Encinas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fcell.2020.00654/full | es_ES |
dc.identifier.doi | 10.3389/fcell.2020.00654 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as 2020 Martín-Suárez, Abiega, Ricobaraza, Hernandez-Alcoceba and Encinas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.