Poly(l-lactide)-Based Anti-Inflammatory Responsive Surfaces for Surgical Implants
dc.contributor.author | Sánchez Bodón, Julia | |
dc.contributor.author | Ruiz Rubio, Leire | |
dc.contributor.author | Hernáez Laviña, Estíbaliz | |
dc.contributor.author | Vilas Vilela, José Luis ![]() | |
dc.contributor.author | Moreno Benítez, María Isabel ![]() | |
dc.date.accessioned | 2021-01-13T12:41:13Z | |
dc.date.available | 2021-01-13T12:41:13Z | |
dc.date.issued | 2020-12-24 | |
dc.identifier.citation | Polymers 13(1) : (2020) // Article ID 34 | es_ES |
dc.identifier.issn | 2073-4360 | |
dc.identifier.uri | http://hdl.handle.net/10810/49742 | |
dc.description.abstract | In the last few decades, surgical implants have been widely used to restore the function of damaged bones or joints. However, it is essential to receive antibiotic or anti-inflammatory treatment to circumvent significant problems associated, such as the colonization of the implanted surface by bacteria or other microorganisms and strong host inflammatory responses. This article presents the effectiveness of the copper catalyzed alkyne-azide cycloaddition (CuAAC) (“click”) reaction by the linkage of a fluorophore to the poly(L-lactide) (PLLA) surface. The results were analysed by means of X-ray photoelectron spectroscopy (XPS), contact angle and fluorescence microscopy. Moreover, this current work describes the covalent immobilization of the anti-inflammatory drug indomethacin on a PLLA surface. The CuAAC click reaction was selected to anchor the drug to the polymeric films. The successful bioconjugation of the drug was confirmed by XPS and the change on the contact angle. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | poly-l-lactide (PLLA) | es_ES |
dc.subject | click reaction | es_ES |
dc.subject | anti-inflammatory activity | es_ES |
dc.title | Poly(l-lactide)-Based Anti-Inflammatory Responsive Surfaces for Surgical Implants | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-01-08T14:44:15Z | |
dc.rights.holder | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2073-4360/13/1/34/htm | es_ES |
dc.identifier.doi | 10.3390/polym13010034 | |
dc.departamentoes | Química física | |
dc.departamentoes | Química inorgánica | |
dc.departamentoes | Química orgánica II | |
dc.departamentoeu | Kimika fisikoa | |
dc.departamentoeu | Kimika ez-organikoa | |
dc.departamentoeu | Kimika organikoa II |
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Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).