Tunable Polymeric Scaffolds for Enzyme Immobilization
dc.contributor.author | Rodríguez Abetxuko, Andoni | |
dc.contributor.author | Sánchez de Alcázar Melendo, Daniel | |
dc.contributor.author | Muñumer, Pablo | |
dc.contributor.author | Beloqui Elizazu, Ana | |
dc.date.accessioned | 2021-01-21T13:26:25Z | |
dc.date.available | 2021-01-21T13:26:25Z | |
dc.date.issued | 2020-07-30 | |
dc.identifier.citation | Frontiers in Bioengineering and Biotechnology 8 : (2020) // Article ID 830 | es_ES |
dc.identifier.issn | 2296-4185 | |
dc.identifier.uri | http://hdl.handle.net/10810/49826 | |
dc.description.abstract | The number of methodologies for the immobilization of enzymes using polymeric supports is continuously growing due to the developments in the fields of biotechnology, polymer chemistry, and nanotechnology in the last years. Despite being excellent catalysts, enzymes are very sensitive molecules and can undergo denaturation beyond their natural environment. For overcoming this issue, polymer chemistry offers a wealth of opportunities for the successful combination of enzymes with versatile natural or synthetic polymers. The fabrication of functional, stable, and robust biocatalytic hybrid materials (nanoparticles, capsules, hydrogels, or films) has been proven advantageous for several applications such as biomedicine, organic synthesis, biosensing, and bioremediation. In this review, supported with recent examples of enzyme-protein hybrids, we provide an overview of the methods used to combine both macromolecules, as well as the future directions and the main challenges that are currently being tackled in this field. | es_ES |
dc.description.sponsorship | This work is in the framework of a project that has received funding from the Spanish Ministry of Economy and Competitiveness (MINECO) and FEDER funds in the frame of "Plan Nacional -Retos para la Sociedad" call with the grant references MAT2017-88808-R and PID2019-110239RB-I00. This work was performed under the Maria de Maeztu Units of Excellence Programme -MDM-2016-0618. AB thanks the Spanish Research Agency (AEI) for the funds within Ramon y Cajal programme (RYC2018-025923-I). AR-A thanks the Basque Government for his Ph.D. fellowship (PRE_2019_2_0147). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/MAT2017-88808-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PID2019-110239RB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | enzyme-polymer hybrids | es_ES |
dc.subject | enzyme immobilization | es_ES |
dc.subject | polymeric supports | es_ES |
dc.subject | biocatalysis | es_ES |
dc.subject | nanocarriers | es_ES |
dc.subject | stabilization of enzymes | es_ES |
dc.subject | metal-organic frameworks | es_ES |
dc.subject | polyion complex vesicles | es_ES |
dc.subject | composite nanofibrous membrane | es_ES |
dc.subject | core-shell nanoparticles | es_ES |
dc.subject | reversible immobilization | es_ES |
dc.subject | radical polymerization | es_ES |
dc.subject | liquid-chromatography | es_ES |
dc.subject | conducting polymer | es_ES |
dc.subject | protein digestion | es_ES |
dc.subject | enhanced activity | es_ES |
dc.title | Tunable Polymeric Scaffolds for Enzyme Immobilization | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2020 Rodriguez-Abetxuko, Sánchez-deAlcázar, Muñumer and Beloqui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fbioe.2020.00830/full | es_ES |
dc.identifier.doi | 10.3389/fbioe.2020.00830 | |
dc.departamentoes | Química aplicada | es_ES |
dc.departamentoeu | Kimika aplikatua | es_ES |
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Except where otherwise noted, this item's license is described as 2020 Rodriguez-Abetxuko, Sánchez-deAlcázar, Muñumer and Beloqui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.