The Host Immune Response to Scedosporium/Lomentospora
dc.contributor.author | Buldain Garriz, Idoia | |
dc.contributor.author | Martín Souto, Leire ![]() | |
dc.contributor.author | Antorán Díaz, Aitziber ![]() | |
dc.contributor.author | Areitio Beramendi, Maialen | |
dc.contributor.author | Aparicio Fernández, Leire | |
dc.contributor.author | Rementeria Ruiz, Aitor Domingo | |
dc.contributor.author | Hernando Echevarria, Fernando Luis | |
dc.contributor.author | Ramírez García, Andoni | |
dc.date.accessioned | 2021-03-02T11:53:07Z | |
dc.date.available | 2021-03-02T11:53:07Z | |
dc.date.issued | 2021-01-22 | |
dc.identifier.citation | Journal of Fungi 7(2) : (2021) // Article ID 75 | es_ES |
dc.identifier.issn | 2309-608X | |
dc.identifier.uri | http://hdl.handle.net/10810/50416 | |
dc.description.abstract | Infections caused by the opportunistic pathogens Scedosporium/Lomentospora are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against these fungi, since an understanding of the mechanisms involved is of great interest in developing more effective strategies against them. Scedosporium/Lomentospora cell wall components, including peptidorhamnomannans (PRMs), α-glucans and glucosylceramides, are important immune response activators following their recognition by TLR2, TLR4 and Dectin-1 and through receptors that are yet unknown. After recognition, cytokine synthesis and antifungal activity of different phagocytes and epithelial cells is species-specific, highlighting the poor response by microglial cells against L. prolificans. Moreover, a great number of Scedosporium/Lomentospora antigens have been identified, most notably catalase, PRM and Hsp70 for their potential medical applicability. Against host immune response, these fungi contain evasion mechanisms, inducing host non-protective response, masking fungal molecular patterns, destructing host defense proteins and decreasing oxidative killing. In conclusion, although many advances have been made, many aspects remain to be elucidated and more research is necessary to shed light on the immune response to Scedosporium/Lomentospora. | es_ES |
dc.description.sponsorship | This research was funded by the Basque Government, grant number IT1362-19. L.M.-S., M.A., and L.A.-F. were funded by the Basque Government. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | scedosporium | es_ES |
dc.subject | lomentospora | es_ES |
dc.subject | immune response | es_ES |
dc.subject | cytokine | es_ES |
dc.subject | macrophage | es_ES |
dc.subject | lymphocyte | es_ES |
dc.subject | monocyte | es_ES |
dc.subject | antigen | es_ES |
dc.subject | epithelium | es_ES |
dc.title | The Host Immune Response to Scedosporium/Lomentospora | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-02-26T14:41:18Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2309-608X/7/2/75/htm | es_ES |
dc.identifier.doi | 10.3390/jof7020075 | |
dc.departamentoes | Inmunología, microbiología y parasitología | |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).