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Hetero-Diels-Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform

dc.contributor.authorBeloqui Elizazu, Ana
dc.contributor.authorMane, Shivshankar R.
dc.contributor.authorLanger, Marcel
dc.contributor.authorGlassner, Mathias
dc.contributor.authorBauer, Dennis M.
dc.contributor.authorFruk, Ljiljana
dc.contributor.authorBarner-Kowollik, Christopher
dc.contributor.authorDelaittre, Guillaume
dc.date.accessioned2021-03-04T09:28:45Z
dc.date.available2021-03-04T09:28:45Z
dc.date.issued2020-11-02
dc.identifier.citationAngewandte Chemie International Edition 59(45) : 19951-19955 (2020)es_ES
dc.identifier.issn1433-7851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/10810/50462
dc.description.abstractWe introduce the bioconjugation of polymers synthesized by RAFT polymerization, bearing no specific functional end group, by means of hetero-Diels-Alder cycloaddition through their inherent terminal thiocarbonylthio moiety with a diene-modified model protein. Quantitative conjugation occurs over the course of a few hours, at ambient temperature and neutral pH, and in the absence of any catalyst. Our technology platform affords thermoresponsive bioconjugates, whose aggregation is solely controlled by the polymer chains.es_ES
dc.description.sponsorshipA.B. thanks the Spanish Research Agency (AEI) for funds within the RamonyCajal program (RYC2018-025923-I) and Retos call (PID2019-110239RB-I00). C.B.-K. acknowledges funding by the Australian Research Council (ARC) in the context of a Laureate Fellowship and continued key support from the Queensland University of Technology (QUT) via its Centre for Materials Science. G.D. thanks the German Federal Ministry of Education and Research (BMBF, Grant No. 031A095C) for funding (Molecular Interaction Engineering program, Biotechnologie 2020+). The Levkin lab (IBCS, KIT) is thanked for access to DLS. Frank Kirschhofer, Boris Kuhl, and Dr Gerald Brenner-Weiss (IFG, KIT) are acknowledged for providing access to and support on MALDI-ToF spectrometry. Open access funding enabled and organized by Projekt DEAL.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/RYC2018-025923-Ies_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2019-110239RB-I00es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectbioconjugationes_ES
dc.subjectDiels-Alder cycloadditiones_ES
dc.subjectend groupes_ES
dc.subjectpolymeres_ES
dc.subjectproteines_ES
dc.subjectconjugationes_ES
dc.subjectstabilityes_ES
dc.subjectglycoles_ES
dc.subjectwelles_ES
dc.subjectpolymerizationes_ES
dc.subjectcopolymerses_ES
dc.subjectchemistryes_ES
dc.subjectbehaviores_ES
dc.subjectdesignes_ES
dc.subjectdruges_ES
dc.titleHetero-Diels-Alder Cycloaddition with RAFT Polymers as Bioconjugation Platformes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0)es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/anie.202005747es_ES
dc.identifier.doi10.1002/anie.202005747
dc.departamentoesQuímica aplicadaes_ES
dc.departamentoeuKimika aplikatuaes_ES


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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0)
Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0)