Advances in Microtechnology for Improved Cytotoxicity Assessment
dc.contributor.author | García Hernando, Maite | |
dc.contributor.author | Benito López, Fernando | |
dc.contributor.author | Basabe Desmonts, Lourdes | |
dc.date.accessioned | 2021-03-16T16:41:11Z | |
dc.date.available | 2021-03-16T16:41:11Z | |
dc.date.issued | 2020-11-20 | |
dc.identifier.citation | Frontiers in Materials 7 : (2020) // Article ID 582030 | es_ES |
dc.identifier.issn | 2296-8016 | |
dc.identifier.uri | http://hdl.handle.net/10810/50655 | |
dc.description.abstract | In vitro cytotoxicity testing is essential in the pharmaceutical and environmental industry to study the effects of potential harmful compounds for human health. Classical assays present several disadvantages: they are commonly based on live-death labelling, are highly time consuming and/or require skilled personnel to be performed. The current trend is to reduce the number of required cells and the time during the analysis, while increasing the screening capability and the accuracy and sensitivity of the assays, aiming single cell resolution. Microfabrication and surface engineering are enabling novel approaches for cytotoxicity assessment, offering high sensitivity and the possibility of automation in order to minimize user intervention. This review aims to overview the different microtechnology approaches available in this field, focusing on the novel developments for high-throughput, dynamic and real time screening of cytotoxic compounds. | es_ES |
dc.description.sponsorship | Funding support from: University of the Basque Country (PIF16/204), the funding support from Gobierno de España, Ministerio de Economía y Competitividad, with Grant No. BIO2016-80417-P (AEI/FEDER, UE) and Gobierno Vasco under grand IT1271-19. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/BIO2016-80417-P | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | microtechnology | es_ES |
dc.subject | lab-on-a-chip | es_ES |
dc.subject | cytotoxicity | es_ES |
dc.subject | surface engineering | es_ES |
dc.subject | microfluidics | es_ES |
dc.subject | sensors | es_ES |
dc.subject | biosensors | es_ES |
dc.subject | single cell | es_ES |
dc.title | Advances in Microtechnology for Improved Cytotoxicity Assessment | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2020 Garcia-Hernando, Benito-Lopez and Basabe-Desmonts. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fmats.2020.582030/full | es_ES |
dc.identifier.doi | 10.3389/fmats.2020.582030 | |
dc.departamentoes | Química analítica | es_ES |
dc.departamentoes | Zoología y biología celular animal | es_ES |
dc.departamentoeu | Kimika analitikoa | es_ES |
dc.departamentoeu | Zoologia eta animalia zelulen biologia | es_ES |
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Except where otherwise noted, this item's license is described as © 2020 Garcia-Hernando, Benito-Lopez and Basabe-Desmonts. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.