Prenatal Exposure to Cigarette Smoke and Anogenital Distance at 4 Years in the INMA-Asturias Cohort
dc.contributor.author | García-Villarino, Miguel | |
dc.contributor.author | Fernández-Iglesias, Rocío | |
dc.contributor.author | Riaño-Galán, Isolina | |
dc.contributor.author | Rodríguez-Dehli, Cristina | |
dc.contributor.author | Babarro Vélez, Izaro ![]() | |
dc.contributor.author | Fernández-Somoano, Ana | |
dc.contributor.author | Tardón, Adonina | |
dc.date.accessioned | 2021-05-17T10:20:19Z | |
dc.date.available | 2021-05-17T10:20:19Z | |
dc.date.issued | 2021-04-29 | |
dc.identifier.citation | International Journal of Environmental Research and Public Health 18(9) : (2021) // Article ID 4774 | es_ES |
dc.identifier.issn | 1660-4601 | |
dc.identifier.uri | http://hdl.handle.net/10810/51411 | |
dc.description.abstract | Smoking by women is associated with adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, low birth weight, infertility, and prolonged time to pregnancy. Anogenital distance (AGD) is a sensitive biomarker of prenatal androgen and antiandrogen exposure. We investigated the effect of smoking and passive smoke exposure during pregnancy on anogenital distance in offspring at 4 years in the INMA-Asturias cohort (Spain). Women were interviewed during pregnancy to collect information on tobacco consumption, and anogenital distance was measured in 381 children: Anoscrotal distance in boys and anofourchetal distance in girls. We also measured maternal urinary cotinine levels at 32 weeks of pregnancy. We constructed linear regression models to analyze the association between prenatal smoke exposure and anogenital distance and adjusted the models by relevant covariates. Reported prenatal smoke exposure was associated with statistically significant increased anogenital index (AGI), both at week 12 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) and at week 32 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) in male children, suggesting altered androgenic signaling. | es_ES |
dc.description.sponsorship | Funding was provided by CIBERESP (PhD employment contract and fellowship for short stays abroad—2019), FIS-FEDER (grants PI04/2018, PI09/02311, PI13/02429, and PI18/00909), Obra Social Cajastur/Fundación Liberbank, and Universidad de Oviedo. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | anogenital distance | es_ES |
dc.subject | maternal cigarette smoking | es_ES |
dc.subject | tobacco smoking | es_ES |
dc.subject | endocrine-disrupting chemicals | es_ES |
dc.title | Prenatal Exposure to Cigarette Smoke and Anogenital Distance at 4 Years in the INMA-Asturias Cohort | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-05-13T14:32:17Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1660-4601/18/9/4774/htm | es_ES |
dc.identifier.doi | 10.3390/ijerph18094774 | |
dc.departamentoes | Psicología Clínica y de la Salud y Metodología de Investigación | |
dc.departamentoeu | Psikologia Klinikoa eta Osasunaren Psikologia eta Ikerketa Metodologia |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).