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dc.contributor.authorHerrero de la Parte, Borja
dc.contributor.authorIrazola Duñabeitia, Mireia
dc.contributor.authorPérez Muñoz, Jorge
dc.contributor.authorRodrigo Arrizabalaga, Irati
dc.contributor.authorIturrizaga Correcher, Sira
dc.contributor.authorMar Medina, Carmen
dc.contributor.authorCastro Ortiz de Pinedo, Kepa ORCID
dc.contributor.authorEtxebarria Loizate, Nestor
dc.contributor.authorPlazaola Muguruza, Fernando ORCID
dc.contributor.authorGarcía Martínez, José Angel
dc.contributor.authorGarcía-Alonso Montoya, Ignacio ORCID
dc.contributor.authorEchevarría Uraga, José Javier
dc.date.accessioned2021-05-27T11:40:55Z
dc.date.available2021-05-27T11:40:55Z
dc.date.issued2021-05-17
dc.identifier.citationNanomaterials 11(5) : (2021) // Article ID 1318es_ES
dc.identifier.issn2079-4991
dc.identifier.urihttp://hdl.handle.net/10810/51647
dc.description.abstractBackground: Hyperthermia (HT) therapy still remains relatively unknown, in terms of both its biological and therapeutic effects. This work aims to analyze the effects of exposure to HT, such as that required in anti-tumor magnetic hyperthermia therapies, using metabolomic and serum parameters routinely analyzed in clinical practice. Methods: WAG/RigHsd rats were assigned to the different experimental groups needed to emulate all of the procedures involved in the treatment of liver metastases by HT. Twelve hours or ten days after the electromagnetic HT (606 kHz and 14 kA/m during 21 min), blood samples were retrieved and liver samples were obtained. 1H-nuclear-magnetic-resonance spectroscopy (1H-NMR) was used to search for possible diagnostic biomarkers of HT effects on the rat liver tissue. All of the data obtained from the hydrophilic fraction of the tissues were analyzed and modeled using chemometric tools. Results: Hepatic enzyme levels were significantly increased in animals that underwent hyperthermia after 12 h, but 10 d later they could not be detected anymore. The metabolomic profile (main metabolic differences were found in phosphatidylcholine, taurine, glucose, lactate and pyruvate, among others) also showed that the therapy significantly altered metabolism in the liver within 12 h (with two different patterns); however, those changes reverted to a control-profile pattern after 10 days. Conclusions: Magnetic hyperthermia could be considered as a safe therapy to treat liver metastases, since it does not induce irreversible physiological changes after application.es_ES
dc.description.sponsorshipThe authors gratefully acknowledge the financial support from the Agencia Estatal De Investigación (AEI) of Spain and the European Regional Development Fund (ERDF) through project CTM2017-84763-C3-1-R and from the Basque Government through project IT-742-13. M.I. is grateful to the University of the Basque Country (EHU/UPV) for her pre- and post-doctoral fellowships and to the Foundation of Jesus de Gangoiti Barrera.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MCIU/CTM2017-84763-C3-1-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjecthyperthermiaes_ES
dc.subjectliver functiones_ES
dc.subjectmetabolomicses_ES
dc.subjectanimal modeles_ES
dc.subjectliver metastaseses_ES
dc.titleBiochemical and Metabolomic Changes after Electromagnetic Hyperthermia Exposure to Treat Colorectal Cancer Liver Implants in Ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2021-05-24T15:06:09Z
dc.rights.holder2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/2079-4991/11/5/1318/htmes_ES
dc.identifier.doi10.3390/nano11051318
dc.departamentoesCirugía, radiología y medicina física
dc.departamentoesQuímica analítica
dc.departamentoesElectricidad y electrónica
dc.departamentoesFísica
dc.departamentoeuKirurgia,erradiologia eta medikuntza fisikoa
dc.departamentoeuKimika analitikoa
dc.departamentoeuElektrizitatea eta elektronika
dc.departamentoeuFisika


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2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).