Biochemical and Metabolomic Changes after Electromagnetic Hyperthermia Exposure to Treat Colorectal Cancer Liver Implants in Rats
dc.contributor.author | Herrero de la Parte, Borja | |
dc.contributor.author | Irazola Duñabeitia, Mireia | |
dc.contributor.author | Pérez Muñoz, Jorge | |
dc.contributor.author | Rodrigo Arrizabalaga, Irati | |
dc.contributor.author | Iturrizaga Correcher, Sira | |
dc.contributor.author | Mar Medina, Carmen | |
dc.contributor.author | Castro Ortiz de Pinedo, Kepa ![]() | |
dc.contributor.author | Etxebarria Loizate, Nestor | |
dc.contributor.author | Plazaola Muguruza, Fernando ![]() | |
dc.contributor.author | García Martínez, José Angel | |
dc.contributor.author | García-Alonso Montoya, Ignacio ![]() | |
dc.contributor.author | Echevarría Uraga, José Javier | |
dc.date.accessioned | 2021-05-27T11:40:55Z | |
dc.date.available | 2021-05-27T11:40:55Z | |
dc.date.issued | 2021-05-17 | |
dc.identifier.citation | Nanomaterials 11(5) : (2021) // Article ID 1318 | es_ES |
dc.identifier.issn | 2079-4991 | |
dc.identifier.uri | http://hdl.handle.net/10810/51647 | |
dc.description.abstract | Background: Hyperthermia (HT) therapy still remains relatively unknown, in terms of both its biological and therapeutic effects. This work aims to analyze the effects of exposure to HT, such as that required in anti-tumor magnetic hyperthermia therapies, using metabolomic and serum parameters routinely analyzed in clinical practice. Methods: WAG/RigHsd rats were assigned to the different experimental groups needed to emulate all of the procedures involved in the treatment of liver metastases by HT. Twelve hours or ten days after the electromagnetic HT (606 kHz and 14 kA/m during 21 min), blood samples were retrieved and liver samples were obtained. 1H-nuclear-magnetic-resonance spectroscopy (1H-NMR) was used to search for possible diagnostic biomarkers of HT effects on the rat liver tissue. All of the data obtained from the hydrophilic fraction of the tissues were analyzed and modeled using chemometric tools. Results: Hepatic enzyme levels were significantly increased in animals that underwent hyperthermia after 12 h, but 10 d later they could not be detected anymore. The metabolomic profile (main metabolic differences were found in phosphatidylcholine, taurine, glucose, lactate and pyruvate, among others) also showed that the therapy significantly altered metabolism in the liver within 12 h (with two different patterns); however, those changes reverted to a control-profile pattern after 10 days. Conclusions: Magnetic hyperthermia could be considered as a safe therapy to treat liver metastases, since it does not induce irreversible physiological changes after application. | es_ES |
dc.description.sponsorship | The authors gratefully acknowledge the financial support from the Agencia Estatal De Investigación (AEI) of Spain and the European Regional Development Fund (ERDF) through project CTM2017-84763-C3-1-R and from the Basque Government through project IT-742-13. M.I. is grateful to the University of the Basque Country (EHU/UPV) for her pre- and post-doctoral fellowships and to the Foundation of Jesus de Gangoiti Barrera. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MCIU/CTM2017-84763-C3-1-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | hyperthermia | es_ES |
dc.subject | liver function | es_ES |
dc.subject | metabolomics | es_ES |
dc.subject | animal model | es_ES |
dc.subject | liver metastases | es_ES |
dc.title | Biochemical and Metabolomic Changes after Electromagnetic Hyperthermia Exposure to Treat Colorectal Cancer Liver Implants in Rats | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-05-24T15:06:09Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2079-4991/11/5/1318/htm | es_ES |
dc.identifier.doi | 10.3390/nano11051318 | |
dc.departamentoes | Cirugía, radiología y medicina física | |
dc.departamentoes | Química analítica | |
dc.departamentoes | Electricidad y electrónica | |
dc.departamentoes | Física | |
dc.departamentoeu | Kirurgia,erradiologia eta medikuntza fisikoa | |
dc.departamentoeu | Kimika analitikoa | |
dc.departamentoeu | Elektrizitatea eta elektronika | |
dc.departamentoeu | Fisika |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).