Genetic Contribution of Endometriosis to the Risk of Developing Hormone-Related Cancers
dc.contributor.author | Rueda Martínez, Aintzane | |
dc.contributor.author | Garitazelaia González, Aiara | |
dc.contributor.author | Cilleros Portet, Ariadna ![]() | |
dc.contributor.author | Marí Alemany, Sergi | |
dc.contributor.author | Arauzo, Rebeca | |
dc.contributor.author | De Miguel, Jokin | |
dc.contributor.author | González García, Bárbara P. | |
dc.contributor.author | Fernández Jiménez, Nora ![]() | |
dc.contributor.author | Bilbao Catalá, José Ramón ![]() | |
dc.contributor.author | García Santisteban, Iraia ![]() | |
dc.date.accessioned | 2021-06-21T11:38:07Z | |
dc.date.available | 2021-06-21T11:38:07Z | |
dc.date.issued | 2021-06-04 | |
dc.identifier.citation | International Journal of Molecular Sciences 22(11) : (2021) // Article ID 6083 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/51967 | |
dc.description.abstract | Endometriosis is a common gynecological disorder that has been associated with endometrial, breast and epithelial ovarian cancers in epidemiological studies. Since complex diseases are a result of multiple environmental and genetic factors, we hypothesized that the biological mechanism underlying their comorbidity might be explained, at least in part, by shared genetics. To assess their potential genetic relationship, we performed a two-sample mendelian randomization (2SMR) analysis on results from public genome-wide association studies (GWAS). This analysis confirmed previously reported genetic pleiotropy between endometriosis and endometrial cancer. We present robust evidence supporting a causal genetic association between endometriosis and ovarian cancer, particularly with the clear cell and endometrioid subtypes. Our study also identified genetic variants that could explain those associations, opening the door to further functional experiments. Overall, this work demonstrates the value of genomic analyses to support epidemiological data, and to identify targets of relevance in multiple disorders. | es_ES |
dc.description.sponsorship | This research was funded by the Basque Department of Health, grant numbers 2020111043, 2018111086 and 2019111085 to I.G.-S., J.R.B. and N.F.-J., respectively. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | endometriosis | es_ES |
dc.subject | hormone-related cancers | es_ES |
dc.subject | epithelial ovarian cancer | es_ES |
dc.subject | breast cancer | es_ES |
dc.subject | endometrial cancer | es_ES |
dc.subject | mendelian randomization | es_ES |
dc.title | Genetic Contribution of Endometriosis to the Risk of Developing Hormone-Related Cancers | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-06-10T13:47:50Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/22/11/6083/htm | es_ES |
dc.identifier.doi | 10.3390/ijms22116083 | |
dc.departamentoes | Genética, antropología física y fisiología animal | |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).