Molecular Mechanisms Regulating the DNA Repair Protein APE1: A Focus on Its Flexible N-Terminal Tail Domain
dc.contributor.author | López Jiménez, David ![]() | |
dc.contributor.author | Rodríguez Pérez, José Antonio ![]() | |
dc.contributor.author | Bañuelos Rodríguez, Sonia ![]() | |
dc.date.accessioned | 2021-07-14T08:25:22Z | |
dc.date.available | 2021-07-14T08:25:22Z | |
dc.date.issued | 2021-06-11 | |
dc.identifier.citation | International Journal of Molecular Sciences 22 (12): (2021) // Article ID 6308 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/52449 | |
dc.description.abstract | APE1 (DNA (apurinic/apyrimidinic site) endonuclease 1) is a key enzyme of one of the major DNA repair routes, the BER (base excision repair) pathway. APE1 fulfils additional functions, acting as a redox regulator of transcription factors and taking part in RNA metabolism. The mechanisms regulating APE1 are still being deciphered. Structurally, human APE1 consists of a well-characterized globular catalytic domain responsible for its endonuclease activity, preceded by a conformationally flexible N-terminal extension, acquired along evolution. This N-terminal tail appears to play a prominent role in the modulation of APE1 and probably in BER coordination. Thus, it is primarily involved in mediating APE1 localization, post-translational modifications, and protein–protein interactions, with all three factors jointly contributing to regulate the enzyme. In this review, recent insights on the regulatory role of the N-terminal region in several aspects of APE1 function are covered. In particular, interaction of this region with nucleophosmin (NPM1) might modulate certain APE1 activities, representing a paradigmatic example of the interconnection between various regulatory factors. | es_ES |
dc.description.sponsorship | This work was supported by a grant from the University of the Basque Country (GIU18/172) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | apurinic/apyrimidinic endonuclease 1 | es_ES |
dc.subject | APE1 | es_ES |
dc.subject | DNA repair | es_ES |
dc.subject | BER pathway | es_ES |
dc.subject | abasic | es_ES |
dc.subject | nucleophosmin | es_ES |
dc.subject | NPM1 | es_ES |
dc.subject | protein regulation | es_ES |
dc.title | Molecular Mechanisms Regulating the DNA Repair Protein APE1: A Focus on Its Flexible N-Terminal Tail Domain | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-06-24T14:12:00Z | |
dc.rights.holder | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/22/12/6308 | es_ES |
dc.identifier.doi | 10.3390/ijms22126308 | |
dc.departamentoes | Genética, antropología física y fisiología animal | |
dc.departamentoes | Bioquímica y biología molecular | |
dc.departamentoeu | Biokimika eta biologia molekularra | |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia |
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Except where otherwise noted, this item's license is described as © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).