Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
dc.contributor.author | López de Ipiña Peña, Miren Karmele | |
dc.contributor.author | Solé Casals, Jordi | |
dc.contributor.author | Sánchez Méndez, José Ignacio | |
dc.contributor.author | Romero Garcia, Rafael | |
dc.contributor.author | Fernández Gómez de Segura, Elsa | |
dc.contributor.author | Requejo Rodríguez, Catalina | |
dc.contributor.author | Poologaindran, Anujan | |
dc.contributor.author | Faúndez Zanuy, Marcos | |
dc.contributor.author | Martí Massó, José Félix | |
dc.contributor.author | Bergareche, Alberto | |
dc.contributor.author | Suckling, John | |
dc.date.accessioned | 2021-07-28T08:44:16Z | |
dc.date.available | 2021-07-28T08:44:16Z | |
dc.date.issued | 2021-06-08 | |
dc.identifier.citation | Frontiers in Human Neuroscience 15 : (2021) // Article ID 648573 | es_ES |
dc.identifier.issn | 1662-5161 | |
dc.identifier.uri | http://hdl.handle.net/10810/52581 | |
dc.description.abstract | [EN] Essential tremor (ET) is a highly prevalent neurological disorder characterized by actioninduced tremors involving the hand, voice, head, and/or face. Importantly, hand tremor is present in nearly all forms of ET, resulting in impaired fine motor skills and diminished quality of life. To advance early diagnostic approaches for ET, automated handwriting tasks and magnetic resonance imaging (MRI) offer an opportunity to develop early essential clinical biomarkers. In this study, we present a novel approach for the early clinical diagnosis and monitoring of ET based on integrating handwriting and neuroimaging analysis. We demonstrate how the analysis of fine motor skills, as measured by an automated Archimedes’ spiral task, is correlated with neuroimaging biomarkers for ET. Together, we present a novel modeling approach that can serve as a complementary and promising support tool for the clinical diagnosis of ET and a large range of tremors. | es_ES |
dc.description.sponsorship | This work was supported in part by the Universidad del País Vasco/Euskal Herriko Unibertsitatea, the University of Cambridge, PPG 17/51 and GIU 092/19, the Basque government (Saiotek SA-2010/00028, ELEKIN, Engineering and Society and Bioengineering Research Groups, GIC18/136, and ELKARTEK 18/99, 20/81), ‘‘Ministerio de Ciencia e Innovación’’ (SAF2016 77758 R), FEDER funds, DomusVi Foundation (FP18/76), and the government of Gipuzkoa (HELENA, SABRINA, DG18/14- 23, DG19/29, DG20/25 projects). This work is also based upon the work from COST Actions CA18106 and CA15225, supported by COST (European Cooperation in Science and Technology). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2016-77758-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | essential tremor | es_ES |
dc.subject | fine motor skills | es_ES |
dc.subject | neuroimaging | es_ES |
dc.subject | handwriting | es_ES |
dc.subject | early management | es_ES |
dc.title | Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | Copyright © 2021 Lopez-de-Ipina, Solé-Casals, Sánchez-Méndez, Romero-Garcia, Fernandez, Requejo, Poologaindran, Faúndez-Zanuy, Martí-Massó, Bergareche and Suckling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fnhum.2021.648573 | es_ES |
dc.identifier.doi | 10.3389/fnhum.2021.648573 | |
dc.departamentoes | Ingeniería de sistemas y automática | es_ES |
dc.departamentoeu | Sistemen ingeniaritza eta automatika | es_ES |
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