dc.contributor.author | Svensson, Emma | |
dc.contributor.author | Günther, Torsten | |
dc.contributor.author | Hoischen, Alexander | |
dc.contributor.author | Hervella Afonso, Montserrat | |
dc.contributor.author | Munters, Arielle R. | |
dc.contributor.author | Ioana, Mihai | |
dc.contributor.author | Ridiche, Florin | |
dc.contributor.author | Edlund, Hanna | |
dc.contributor.author | Van Deuren, Rosanne C. | |
dc.contributor.author | Soficaru, Andrei Dorian | |
dc.contributor.author | De la Rúa Vaca, Concepción | |
dc.contributor.author | Netea, Mihai G. | |
dc.contributor.author | Jakobsson, Mattias | |
dc.date.accessioned | 2021-08-13T07:50:14Z | |
dc.date.available | 2021-08-13T07:50:14Z | |
dc.date.issued | 2021-07-26 | |
dc.identifier.citation | Current Biology 31 : 2973–2983 (2021) | es_ES |
dc.identifier.issn | 0960-9822 | |
dc.identifier.issn | 1879-0445 | |
dc.identifier.uri | http://hdl.handle.net/10810/52864 | |
dc.description.abstract | [EN] Few complete human genomes from the European Early Upper Palaeolithic (EUP) have been sequenced.
Using novel sampling and DNA extraction approaches, we sequenced the genome of a woman from ‘‘Pesxtera
Muierii,’’ Romania who lived 34,000 years ago to 13.53 coverage. The genome shows similarities to modern-
day Europeans, but she is not a direct ancestor. Although her cranium exhibits both modern human and
Neanderthal features, the genome shows similar levels of Neanderthal admixture ( 3.1%) to most EUP
humans but only half compared to the 40,000-year-old Pesxtera Oase 1. All EUP European hunter-gatherers
display high genetic diversity, demonstrating that the severe loss of diversity occurred during and after the
Last Glacial Maximum (LGM) rather than just during the out-of-Africa migration. The prevalence of genetic
diseases is expected to increase with low diversity; however, pathogenic variant load was relatively constant
from EUP to modern times, despite post-LGM hunter-gatherers having the lowest diversity ever observed
among Europeans. | es_ES |
dc.description.sponsorship | The computations were performed on resources provided by SNIC through
Uppsala Multidisciplinary Center for Advanced Computational Science
(UPPMAX). Sequencing was performed by the SNP&SEQ Technology Platform
in Uppsala. T.G. was supported by a grant from the Swedish Research
Council Vetenskapsra° det (2017-05267). M.G.N. was supported by a Spinoza
grant of the Netherlands Organisation for Scientific Research and an ERC
Advanced Grant (no. 833247). M.J. was supported by an ERC Starting Grant
and the Knut and Alice Wallenberg Foundation. C.R. was supported by a Basque
Government Grant to Research Groups of the Basque University System
(IT1138-16). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.title | Genome of Peștera Muierii skull shows high diversity and low mutational load in pre-glacial Europe | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0960982221005923 | es_ES |
dc.identifier.doi | 10.1016/j.cub.2021.04.045 | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |