dc.contributor.author | Díez Villalba, Ander | |
dc.contributor.author | Carrano, Giulia ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.contributor.author | Bregón Villahoz, Marta | |
dc.contributor.author | Cuétara García, María Soledad | |
dc.contributor.author | García Ruiz, Juan Carlos | |
dc.contributor.author | Fernández de Larrinoa Santamaría, Iñigo | |
dc.contributor.author | Moragues Tosantos, María Dolores ![ORCID](/themes/Mirage2//images/orcid_16x16.png) | |
dc.date.accessioned | 2021-10-07T08:35:21Z | |
dc.date.available | 2021-10-07T08:35:21Z | |
dc.date.issued | 2021-07-24 | |
dc.identifier.citation | Diagnostic Microbiology and Infectious Disease 101(3) : (2021) // Article ID 115509 | es_ES |
dc.identifier.issn | 1879-0070 | |
dc.identifier.uri | http://hdl.handle.net/10810/53271 | |
dc.description.abstract | Blood culture methods show low sensitivity, so reliable non-culture diagnostic tests are needed to help clinicians with the introduction, de-escalation, and discontinuation of antifungal therapy in patients with suspected invasive candidiasis (IC). We evaluated different biomarkers for the diagnosis of IC in immunocompetent and immunocompromised patients at risk for developing invasive fungal diseases. The specificity of Candida albicans germ-tube antibodies (CAGTA) detection was high (89%-100%), but sensitivity did not exceed 61% even after raising the cut-off from 1/160 to 1/80. We developed enzyme-linked immunoassays detecting antibodies against C. albicans proteins (Als3-N, Hwp1-N, or Met6) that resulted more sensitive (66%-92%) but less specific than CAGTA assay. The combination of 1,3-beta-D-glucan (BDG) detection and CAGTA results provided the highest diagnostic usefulness in immunocompetent patients. However, in immunocompromised patients, anti-Met6 antibodies was the best biomarker, both, alone or in combination with BDG | es_ES |
dc.description.sponsorship | This work was supported by the Basque Government (Groups of Research IT913-16; GIC15/103). Marta Bregón-Villahoz received a grant from the University of the Basque Country UPV/EHU (PIF19/316). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Als3 | es_ES |
dc.subject | CAGTA | es_ES |
dc.subject | diagnosis | es_ES |
dc.subject | Hwp1 | es_ES |
dc.subject | Invasive candidiasis | es_ES |
dc.subject | Met6 | es_ES |
dc.title | Biomarkers for the diagnosis of invasive candidiasis in immunocompetent and immunocompromised patients | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY-NC-ND 4.0) | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www-sciencedirect-com.ehu.idm.oclc.org/science/article/pii/S0732889321002017?via%3Dihub#! | es_ES |
dc.identifier.doi | 10.1016/j.diagmicrobio.2021.115509 | |
dc.departamentoes | Enfermería | es_ES |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoes | Química aplicada | es_ES |
dc.departamentoeu | Erizaintza | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
dc.departamentoeu | Kimika aplikatua | es_ES |