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Late-Stage C-H Acylation of Tyrosine-Containing Oligopeptides with Alcohols

dc.contributor.authorUrruzuno Guiu, Iñaki
dc.contributor.authorAndrade Sampedro, Paula
dc.contributor.authorCorrea Navarro, Arkaitz ORCID
dc.date.accessioned2021-10-15T07:49:54Z
dc.date.available2021-10-15T07:49:54Z
dc.date.issued2021-09-17
dc.identifier.citationOrganic Letters 23(18) : 7279-7284 (2021)es_ES
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.urihttp://hdl.handle.net/10810/53370
dc.description.abstractThe selective tagging of amino acids within a peptide framework while using atom-economical C-H counterparts poses an unmet challenge within peptide chemistry. Herein, we report a novel Pd-catalyzed late-stage C-H acylation of a collection of Tyr-containing peptides with alcohols. This water-compatible labeling technique is distinguished by its reliable scalability and features the use of ethanol as a renewable feedstock for the assembly of a variety of peptidomimetics.es_ES
dc.description.sponsorshipThe authors are grateful to the Ministerio de Ciencia e Innovacion (RTI2018-093721-B-I00, MCI/AEI/FEDER, UE) and the Basque Government (IT1033-16) for financial support. The authors thank the technical and human support provided by the Central Service of Analysis-SGIker of UPV/EHU and European funding (ERDF and ESF). In~aki Urruzuno thanks UPV/EHU for the postdoctoral research grant (EspDoc2020)es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/RTI2018-093721-B-I00es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectcatalyzed ortho-alkoxylationes_ES
dc.subjectbondes_ES
dc.subjectfunctionalizationes_ES
dc.subjectderivativeses_ES
dc.subjectactivationes_ES
dc.subjectpeptideses_ES
dc.subjecttoolboxes_ES
dc.subjectphenolses_ES
dc.subjectethanoles_ES
dc.subjectacidses_ES
dc.titleLate-Stage C-H Acylation of Tyrosine-Containing Oligopeptides with Alcoholses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0)es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://pubs-acs-org.ehu.idm.oclc.org/doi/10.1021/acs.orglett.1c02764es_ES
dc.identifier.doi10.1021/acs.orglett.1c02764
dc.departamentoesQuímica Orgánica e Inorgánicaes_ES
dc.departamentoesQuímica orgánica Ies_ES
dc.departamentoeuKimika Organikoa eta Ez-Organikoaes_ES
dc.departamentoeuKimika organikoa Ies_ES


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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0)
Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0)