Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
dc.contributor.author | Estévez-Vázquez, Olga | |
dc.contributor.author | Benedé-Ubieto, Raquel | |
dc.contributor.author | Guo, Feifei | |
dc.contributor.author | Gómez Santos, Beatriz | |
dc.contributor.author | Aspichueta Celaá, Patricia | |
dc.contributor.author | Reissing, Johanna | |
dc.contributor.author | Bruns, Tony | |
dc.contributor.author | Sanz-García, Carlos | |
dc.contributor.author | Sydor, Svenja | |
dc.contributor.author | Bechmann, Lars P. | |
dc.contributor.author | Maranillo, Eva | |
dc.contributor.author | Sañudo, José Ramón | |
dc.contributor.author | Vázquez, María Teresa | |
dc.contributor.author | Lamas-Paz, Arantza | |
dc.contributor.author | Morán, Laura | |
dc.contributor.author | Mazariegos, Marina S. | |
dc.contributor.author | Ciudin, Andreea | |
dc.contributor.author | Pericàs, Juan M. | |
dc.contributor.author | Peligros, María Isabel | |
dc.contributor.author | Vaquero, Javier | |
dc.contributor.author | Martínez-Naves, Eduardo | |
dc.contributor.author | Liedtke, Christian | |
dc.contributor.author | Regueiro, José R. | |
dc.contributor.author | Trautwein, Christian | |
dc.contributor.author | Bañares, Rafael | |
dc.contributor.author | Cubero, Francisco Javier | |
dc.contributor.author | Nevzorova, Yulia A. | |
dc.date.accessioned | 2021-10-26T09:59:06Z | |
dc.date.available | 2021-10-26T09:59:06Z | |
dc.date.issued | 2021-09-22 | |
dc.identifier.citation | Biomedicines 9(10) : (2021) // Article ID 1289 | es_ES |
dc.identifier.issn | 2227-9059 | |
dc.identifier.uri | http://hdl.handle.net/10810/53631 | |
dc.description.abstract | Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD). Methods: C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD—low concentration of PA (main fat source—corn and soybean oils); 2. HP-WD—high concentration of PA (main fat source—palm oil); 3. HP-Trans-WD—high concentration of PA (mainly transfat). Results: All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups. Conclusions: HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD. | es_ES |
dc.description.sponsorship | This work was supported by the MINECO Retos SAF2016-78711, SAF2017-87919-R, PID2020-117827RB-IOO, PID2020-117941RB-IOO, EXOHEP-CM S2017/BMD-3727, NanoLiver-CM Y2018/NMT-4949, AMMF 2018/117, COST Action CA17112 and UCM-25/2019, German Research Foundation (SFB/TRR57/P04, SFB 1382-403224013/A02). F.J.C. and Y.A.N. are Ramón y Cajal Researchers RYC-2014-15242 and RYC-2015-17438. F.J.C. is a Gilead Liver Research Scholar. The research group belongs to the validated Research Groups Ref. 970935 ¨Liver Pathophysiology¨, 920631 ¨Lymphocyte immunobiology¨, 920361 “Inmunogenética e6937 inmunología de las mucosas” and IBL-6 (imas12-associated). O.E.-V. is supported by Beca FPI (associated with MINECO SAF2017-87919R), C.-S.G. by Atracción de Talento 2019-T1/BMD-1331 and R.B.-U. by Contratos predoctorales de personal investigador en formación UCM-Banco Santander (CT63/19). F.G. is a Chinese Scholarship Council (CSC) fellow. T.B. is supported by the German Research Foundation SFB 1382-403224013/B07, and P.A. by Ayudas para apoyar grupos de investigación del sistema Universitario Vasco (IT971-16) and MCIU/AEI/FEDER, UE (RTI2018-095134-B-100). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2016-78711 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2017-87919-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PID2020-117827RB-IOO | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PID2020-117941RB-IOO | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/EXOHEP-CM S2017/BMD-3727 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC-2014-15242 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC-2015-17438. | es_ES |
dc.relation | info:eu-repo/grantAgreement/MCIU/RTI2018-095134-B-100 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | obesity | es_ES |
dc.subject | metabolic associated fatty liver disease (MAFLD) | es_ES |
dc.subject | steatohepatitis | es_ES |
dc.subject | fibrosis | es_ES |
dc.subject | palmitic acid (PA) | es_ES |
dc.title | Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-10-22T13:55:42Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2227-9059/9/10/1289/htm | es_ES |
dc.identifier.doi | 10.3390/biomedicines9101289 | |
dc.departamentoes | Fisiología | |
dc.departamentoeu | Fisiologia |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).