A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users
dc.contributor.author | Mallah, Narmeen | |
dc.contributor.author | Zapata Cachafeiro, Maruxa | |
dc.contributor.author | Aguirre Gómez, Carmelo | |
dc.contributor.author | Ibarra García, Eguzkiñe | |
dc.contributor.author | Palacios Zabalza, Itziar | |
dc.contributor.author | Macías Garcia, Fernando | |
dc.contributor.author | Iglesias García, Julio | |
dc.contributor.author | Piñeiro Lamas, María | |
dc.contributor.author | Ibáñez, Luisa | |
dc.contributor.author | Vidal, Xavier | |
dc.contributor.author | Vendrell, Lourdes | |
dc.contributor.author | Martín Arias, Luis | |
dc.contributor.author | Sainz Gil, María | |
dc.contributor.author | Velasco González, Verónica | |
dc.contributor.author | Salgado Barreira, Ángel | |
dc.contributor.author | Figueiras, Adolfo | |
dc.date.accessioned | 2021-11-26T09:49:11Z | |
dc.date.available | 2021-11-26T09:49:11Z | |
dc.date.issued | 2021-10-07 | |
dc.identifier.citation | Scientific Reports 11(1) : (2021) // Article ID 19923 | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10810/54122 | |
dc.description.abstract | [EN]Bleeding in non-steroidal anti-inflammatory drug (NSAID) users limited their prescription. This first multicenter full case-control study (325 cases and 744 controls), explored the association of e-NOS intron 4 variable number tandem repeat (VNTR) polymorphism with upper gastrointestinal hemorrhage (UGIH) in NSAID exposed and unexposed populations and assessed any interaction between this polymorphism and NSAIDs. NSAID users carrying e-NOS intron 4 wild type genotype or VNTR polymorphism have higher odds of UGIH than those unexposed to NSAIDs [Odds Ratio (OR): 6.62 (95% Confidence Interval (CI): 4.24, 10.36) and OR: 5.41 (95% CI 2.62, 11.51), respectively], with no effect modification from VNTR polymorphism-NSAIDs interaction [Relative Excess Risk due to Interaction (RERI): -1.35 (95% CI -5.73, 3.03); Synergism Index (S): 0.77 (95% CI 0.31, 1.94)]. Similar findings were obtained for aspirin exposure. Non-aspirin NSAID users who carry e-NOS intron 4 VNTR polymorphism have lower odds of UGIH [OR: 4.02 (95% CI 1.85, 8.75) than those users with wild type genotype [OR: 6.52 (95% CI 4.09, 10.38)]; though the interaction estimates are not statistically significant [RERI: -2.68 (95% CI -6.67, 1.31); S: 0.53 (95% CI 0.18, 1.55)]. This exploratory study suggests that the odds of UGIH in NSAID or aspirin users does not modify according to patient ' s e-NOS intron 4 genotype. | es_ES |
dc.description.sponsorship | This work was supported by a grant from Instituto de Salud Carlos III [PI12/02414]/Plan Estatal de I + D + I 2012-2016; Fondo Europeo de Desarrollo Regional (FEDER); the Novartis, Pfizer and Dr Esteve pharmaceutical companies; the Health Research Fund/Fondo de Investigacion Sanitaria [PI021512, PI021364, PI020661, PI021572]; Ministry of Health & Consumer Affairs, Spain [SAF2002-04057]; Galician Regional Authority, Spain [PGIDIT03PXIC20806PN]; Department of Health of the Basque Country [03/11092 and 11/111103]; and Fundacion vasca de innovacin e investigacin sanitarias [OSIBG19/002 and OSIBG18/105]. The genotyping service was carried out at CEGEN-PRB3-ISCIII; Instituto de Salud Carlos III and ERDF [PT17/0019, of the PE I + D + I 2013-2016]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Research | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | nitric-oxide synthase | es_ES |
dc.subject | nonsteroidal antiinflammatory drugs | es_ES |
dc.subject | low-dose aspirin | es_ES |
dc.subject | hardy-weinberg equilibrium | es_ES |
dc.subject | glycoprotein-ib-alpha | es_ES |
dc.subject | gene polymorphisms | es_ES |
dc.subject | variable number | es_ES |
dc.subject | risk | es_ES |
dc.subject | association | es_ES |
dc.subject | prevention | es_ES |
dc.title | A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-021-99402-w | es_ES |
dc.identifier.doi | 10.1038/s41598-021-99402-w | |
dc.departamentoes | Farmacología | es_ES |
dc.departamentoeu | Farmakologia | es_ES |
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