dc.contributor.author | Laguna Egea, Juan Carlos | |
dc.contributor.author | Alegret Jordá, Marta | |
dc.contributor.author | Cofán, Montserrat | |
dc.contributor.author | Sánchez Tainta, Ana | |
dc.contributor.author | Díaz López, Andrés | |
dc.contributor.author | Martínez González, Miguel Ángel | |
dc.contributor.author | Sorli, José Vicente | |
dc.contributor.author | Salas Salvadó, Jordi | |
dc.contributor.author | Fitó, Montserrat | |
dc.contributor.author | Alonso Gómez, Ángel María | |
dc.contributor.author | Serra Majem, Lluís | |
dc.contributor.author | Lapetra, José | |
dc.contributor.author | Fiol, Miquel | |
dc.contributor.author | Gómez Gracia, Enrique | |
dc.contributor.author | Pintó, Xavier | |
dc.contributor.author | Muñoz, Miguel Ángel | |
dc.contributor.author | Castañer, Olga | |
dc.contributor.author | Ramírez Sabio, Judith B. | |
dc.contributor.author | Portu Zapirain, José Joaquín | |
dc.contributor.author | Estruch, Ramón | |
dc.contributor.author | Ros, Emilio | |
dc.date.accessioned | 2021-11-29T08:42:45Z | |
dc.date.available | 2021-11-29T08:42:45Z | |
dc.date.issued | 2021-10 | |
dc.identifier.citation | Clinical Nutrition 40(10) : 5269-5277 (2021) | es_ES |
dc.identifier.issn | 0261-5614 | |
dc.identifier.issn | 1532-1983 | |
dc.identifier.uri | http://hdl.handle.net/10810/54153 | |
dc.description.abstract | [EN]Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mor-tality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 +/- 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality. | es_ES |
dc.description.sponsorship | This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigaciones Sanitarias (FIS), which is co-funded by the European Regional Development Fund (FIS projects, PI04-2239, PI05/2368, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, and P11/02505), Spanish Ministry of Economy, Industry and Competitiveness (SAF2017-82369-R, AGL-2009-13906-C02, and AGL2010-22319-C03), Generalitat de Catalunya (2017 SGR 38), Generalitat Valenciana (GV2016-141), Fundacion Mapfre 2010, Consejeria de Salud de la Junta de Andalucia (PI0105/2007), and Regional Government of Navarra (P27/2011). The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2017-82369-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/AGL-2009-13906-C02 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/AGL2010-22319-C03 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | observational study | es_ES |
dc.subject | dietary sugar | es_ES |
dc.subject | fructose | es_ES |
dc.subject | glucose | es_ES |
dc.subject | fruit juice | es_ES |
dc.subject | liquid form | es_ES |
dc.title | Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0261561421003678?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.clnu.2021.07.031 | |
dc.departamentoes | Medicina | es_ES |
dc.departamentoeu | Medikuntza | es_ES |