Mostrar el registro sencillo del ítem
Dopamine D4 Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum
dc.contributor.author | Rivera, Alicia | |
dc.contributor.author | Suárez-Boomgaard, Diana | |
dc.contributor.author | Miguélez Palomo, Cristina | |
dc.contributor.author | Valderrama-Carvajal, Alejandra | |
dc.contributor.author | Baufreton, Jérôme | |
dc.contributor.author | Shumilov, Kirill | |
dc.contributor.author | Taupignon, Anne | |
dc.contributor.author | Gago, Belén | |
dc.contributor.author | Real, M. Ángeles | |
dc.date.accessioned | 2022-01-13T09:24:29Z | |
dc.date.available | 2022-01-13T09:24:29Z | |
dc.date.issued | 2021-12-23 | |
dc.identifier.citation | Cells 11(1) : (2022) // Article ID 31 | es_ES |
dc.identifier.issn | 2073-4409 | |
dc.identifier.uri | http://hdl.handle.net/10810/54931 | |
dc.description.abstract | Long-term exposition to morphine elicits structural and synaptic plasticity in reward-related regions of the brain, playing a critical role in addiction. However, morphine-induced neuroadaptations in the dorsal striatum have been poorly studied despite its key function in drug-related habit learning. Here, we show that prolonged treatment with morphine triggered the retraction of the dendritic arbor and the loss of dendritic spines in the dorsal striatal projection neurons (MSNs). In an attempt to extend previous findings, we also explored whether the dopamine D4 receptor (D4R) could modulate striatal morphine-induced plasticity. The combined treatment of morphine with the D4R agonist PD168,077 produced an expansion of the MSNs dendritic arbors and restored dendritic spine density. At the electrophysiological level, PD168,077 in combination with morphine altered the electrical properties of the MSNs and decreased their excitability. Finally, results from the sustantia nigra showed that PD168,077 counteracted morphine-induced upregulation of μ opioid receptors (MOR) in striatonigral projections and downregulation of G protein-gated inward rectifier K+ channels (GIRK1 and GIRK2) in dopaminergic cells. The present results highlight the key function of D4R modulating morphine-induced plasticity in the dorsal striatum. Thus, D4R could represent a valuable pharmacological target for the safety use of morphine in pain management. | es_ES |
dc.description.sponsorship | This research was funded by: Junta de Andalucía (Spain) (P09-CVI-4702 and CTS-0161 to A.R); French National Research Agency (ANR-15-CE37-0006 to J.B. and A.T.); LABEX BRAIN (ANR-10-LABX-43 to J.B. and A.T.); Basque Government (Spain) (PUE21-03 to C.M); UPV/EHU (Spain) (COLAB20/07 to C.M). The University of Málaga, University of Bordeaux and CNRS provided infrastructural support. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | dopamine | es_ES |
dc.subject | morphine | es_ES |
dc.subject | addiction | es_ES |
dc.subject | dopamine D4 receptor | es_ES |
dc.subject | caudate putamen | es_ES |
dc.subject | plasticity | es_ES |
dc.subject | receptor–receptor interaction | es_ES |
dc.title | Dopamine D4 Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-01-10T14:37:54Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2073-4409/11/1/31/htm | es_ES |
dc.identifier.doi | 10.3390/cells11010031 | |
dc.departamentoes | Farmacología | |
dc.departamentoeu | Farmakologia |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
Excepto si se señala otra cosa, la licencia del ítem se describe como 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).