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dc.contributor.authorSanz Echevarría, María Begoña
dc.contributor.authorRezola Pardo, Chloe ORCID
dc.contributor.authorArrieta Etxeberria, Haritz
dc.contributor.authorFernández Atucha, Ainhoa
dc.contributor.authorLora Díaz, Inmaculada
dc.contributor.authorGil Goicouría, Francisco Javier ORCID
dc.contributor.authorRodríguez Larrad, Ana
dc.contributor.authorIrazusta Astiazaran, Jon ORCID
dc.date.accessioned2022-01-13T11:41:28Z
dc.date.available2022-01-13T11:41:28Z
dc.date.issued2022-02
dc.identifier.citationExperimental Gerontology 158 : (2022) // Article ID 111655es_ES
dc.identifier.issn0531-5565
dc.identifier.issn1873-6815
dc.identifier.urihttp://hdl.handle.net/10810/54937
dc.description.abstract[EN]Angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) are two of the main components of the renin-angiotensin system (RAS). Imbalanced RAS showing lower ACE2 has been associated with increased cardiovascular risk, muscular pathologies, sarcopenia, frailty, other age-related pathologies and a poorer health status. However, its role in aging remains unclear. Thus, the aim of this work was to analyze the serum enzymatic activity of ACE and ACE2, the ACE/ACE2 ratio and its association with anthropometric parameters, blood pressure, physical function, dependence and frailty in older people living in nursing homes. This study is a secondary analysis of baseline data from two randomized clinical trials in a population of 228 older individuals living in nursing homes (Spain). Serum ACE and ACE2 enzymatic activities were measured by fluorimetry. Variables linked to cardiovascular risk, physical function, dependence and frailty were measured using validated tests, indexes and scales. Association between ACE, ACE2 serum activities, the ACE/ACE2 ratio and the rest of the quantitative variables were assessed by Pearson's correlations and by partial correlations controlled by age and sex. The association between serum ACE and ACE2 activities, the ACE/ACE2 ratio and frailty scores was analyzed by generalized linear models with and without controlling for sex and age. Differences in enzymatic activities between sexes and between frail and non-frail individuals were analyzed using Student's t-test and general linear models to control analysis by age and sex. We found that higher serum ACE2 activity was associated with a higher body mass index, worse physical function, greater dependence and increased frailty. This association is consistent with the elevation of circulating ACE2 in certain pathological conditions and in line with RAS deregulation in muscular dystrophies. Serum ACE2 activity, in combination with other molecules, could be proposed as a biomarker of poor physical function, higher dependence and frailty.es_ES
dc.description.sponsorshipThis work was supported by grants from the Basque government (ELKARTEK19/78, SAN20/12) , and the University of the Basque Country (GIU17/19, GIU20/006) . Haritz Arrieta and Chloe Rezola were supported by two fellowships from the University of the Basque Country (UPV/EHU) . Open Access funding provided by University of Basque Country. The sponsors did not have a role in the design of the study, nor in the collection, analysis, and interpretation of data, nor in writing the manuscript.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectangiotensin-converting enzyme 2es_ES
dc.subjectbiomarkeres_ES
dc.subjectfrailtyes_ES
dc.subjectphysical functiones_ES
dc.subjectnursing homees_ES
dc.titleHigh serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residentses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2021 The Author(s). This is an open access article under the CC BY-NC-ND license.es_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas 3.0 España*
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S053155652100437X?via%3Dihubes_ES
dc.identifier.doi10.1016/j.exger.2021.111655
dc.departamentoesEnfermería IIes_ES
dc.departamentoesFisiologíaes_ES
dc.departamentoeuErizaintza IIes_ES
dc.departamentoeuFisiologiaes_ES


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© 2021 The Author(s). This is an open access article under the CC BY-NC-ND license.
Except where otherwise noted, this item's license is described as © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license.