dc.contributor.author | Fuertes Sánchez, María | |
dc.contributor.author | Selas Lanseros, Asier | |
dc.contributor.author | Trejo, Ángela | |
dc.contributor.author | Knudsen, Birgitta R. | |
dc.contributor.author | Palacios Gambra, Francisco Javier | |
dc.contributor.author | Alonso Pérez, Concepción Estibaliz | |
dc.date.accessioned | 2022-01-14T09:03:33Z | |
dc.date.available | 2022-01-14T09:03:33Z | |
dc.date.issued | 2022-02-01 | |
dc.identifier.citation | Bioorganic & Medicinal Chemistry Letters 57 : (2022) : // Article ID 128517 | es_ES |
dc.identifier.issn | 1464-3405 | |
dc.identifier.uri | http://hdl.handle.net/10810/54981 | |
dc.description.abstract | [EN]This work describes the first synthesis of diethyl 6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinolinylphosphonates 5, diethyl 7H-indeno[2,1-c]quinolinylphosphonates 6 and diethyl 7-oxo-7H-indeno[2,1-c]quinolinylphosphonates 7, which were prepared in good to high overall yields. The synthetic route involves a multicomponent reaction of 2-phosphonateaniline, aldehydes and indene as olefin and allows the selective generation of three stereogenic centres in a short, efficient and reliable manner. The selective dehydrogenation of 1,2,3,4-tetrahydroindenoquinolines leads to the formation of corresponding indenoquinolines, and subsequent oxidation of methylene group of the indenoquinolines allows the access to indenoquinolinones. | es_ES |
dc.description.sponsorship | Financial support from the Ministerio de Ciencia, Innovación y Universidades (MCIU), Agencia Estatal de Investigación (AEI) y Fondo Europeo de Desarrollo Regional (FEDER; RTI2018-101818-B-I00, UE) and by Gobierno Vasco, Universidad del País Vasco (GV, IT 992-16; UPV) is gratefully acknowledged. Technical and human support provided by IZO-SGI, SGIker (UPV/EHU, MICINN, GV/EJ, ERDF and ESF) is gratefully acknowledged. AS thanks the Basque Government for a formation contract. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RTI2018-101818-B-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | indenoquinolinyl phosphonates | es_ES |
dc.subject | topoisomerase I | es_ES |
dc.subject | enzyme inhibition | es_ES |
dc.subject | antiproliferative effect | es_ES |
dc.title | Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license. | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0960894X21007447?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.bmcl.2021.128517 | |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |