Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder
dc.contributor.author | Caso, Javier R. | |
dc.contributor.author | MacDowell, Karina S. | |
dc.contributor.author | González Pinto Arrillaga, Ana María ![]() | |
dc.contributor.author | García Fernández, Saínza | |
dc.contributor.author | De Diego Adeliño, Javier | |
dc.contributor.author | Carceller Sindreu, Mar | |
dc.contributor.author | Sarramea, Fernando | |
dc.contributor.author | Caballero Villarraso, Javier | |
dc.contributor.author | Gracia García, Patricia | |
dc.contributor.author | de la Cámara Izquierdo, Concepción | |
dc.contributor.author | Agüera Ortíz, Luis | |
dc.contributor.author | Gómez Lus Centelles, María Luisa | |
dc.contributor.author | Alba Rubio, Claudio | |
dc.contributor.author | Rodríguez, Juan M. | |
dc.contributor.author | Leza Cerro, Juan Carlos | |
dc.date.accessioned | 2022-01-17T09:29:09Z | |
dc.date.available | 2022-01-17T09:29:09Z | |
dc.date.issued | 2021-12-21 | |
dc.identifier.citation | Translational Psychiatry 11(1) : (2021) // Article ID 645 | es_ES |
dc.identifier.issn | 2158-3188 | |
dc.identifier.uri | http://hdl.handle.net/10810/55014 | |
dc.description.abstract | [EN] Although alterations in the gut microbiota have been linked to the pathophysiology of major depressive disorder (MDD), including through effects on the immune response, our understanding is deficient about the straight connection patterns among microbiota and MDD in patients. Male and female MDD patients were recruited: 46 patients with a current active MDD (a-MDD) and 22 in remission or with only mild symptoms (r-MDD). Forty-five healthy controls (HC) were also recruited. Psychopathological states were assessed, and fecal and blood samples were collected. Results indicated that the inducible nitric oxide synthase expression was higher in MDD patients compared with HC and the oxidative stress levels were greater in the a-MDD group. Furthermore, the lipopolysaccharide (an indirect marker of bacterial translocation) was higher in a-MDD patients compared with the other groups. Fecal samples did not cluster according to the presence or the absence of MDD. There were bacterial genera whose relative abundance was altered in MDD: Bilophila (2-fold) and Alistipes (1.5-fold) were higher, while Anaerostipes (1.5-fold) and Dialister (15-fold) were lower in MDD patients compared with HC. Patients with a-MDD presented higher relative abundance of Alistipes and Anaerostipes (1.5-fold) and a complete depletion of Dialister compared with HC. Patients with r-MDD presented higher abundance of Bilophila (2.5-fold) compared with HC. Thus, the abundance of bacterial genera and some immune pathways, both with potential implications in the pathophysiology of depression, appear to be altered in MDD, with the most noticeable changes occurring in patients with the worse clinical condition, the a-MDD group. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Spanish Ministries of Health-ISCIII (FIS PI13/01102) and MICINN-FEDER Funds (SAF2016-75500-R and PID2019-109033RB-I00) to JCL and by CIBERSAM. JRC is a Ramon y Cajal Researcher (Spanish Ministry of Science and Innovation and FEDER). JdD-A was supported by the Catalan Intensification Programme (PERIS, SLT008/18/00092; Generalitat de Catalunya). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2016-75500-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-109033RB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | butyrate-producing bacterium | es_ES |
dc.subject | necrosis-factor-alpha | es_ES |
dc.subject | sp-nov | es_ES |
dc.subject | psychometric properties | es_ES |
dc.subject | fecal microbiota | es_ES |
dc.subject | gene-expression | es_ES |
dc.subject | spanish version | es_ES |
dc.subject | metaanalysis | es_ES |
dc.subject | stress | es_ES |
dc.subject | impact | es_ES |
dc.title | Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41398-021-01755-3 | es_ES |
dc.identifier.doi | 10.1038/s41398-021-01755-3 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.