pH-Induced 3D Printable Chitosan Hydrogels for Soft Actuation
dc.contributor.author | Maiz Fernández, Sheila | |
dc.contributor.author | Pérez Álvarez, Leyre | |
dc.contributor.author | Silván, Unai | |
dc.contributor.author | Vilas Vilela, José Luis ![]() | |
dc.contributor.author | Lanceros Méndez, Senentxu | |
dc.date.accessioned | 2022-02-18T15:44:02Z | |
dc.date.available | 2022-02-18T15:44:02Z | |
dc.date.issued | 2022-02-08 | |
dc.identifier.citation | Polymers 14(3) : (2022) // Article ID 650 | es_ES |
dc.identifier.issn | 2073-4360 | |
dc.identifier.uri | http://hdl.handle.net/10810/55524 | |
dc.description.abstract | Three-dimensional (3D) printing represents a suitable technology for the development of biomimetic scaffolds for biomedical and tissue engineering applications. However, hydrogel-based inks’ printability remains a challenge due to their restricted print accuracy, mechanical properties, swelling or even cytotoxicity. Chitosan is a natural-derived polysaccharide that has arisen as a promising bioink due to its biodegradability, biocompatibility, sustainability and antibacterial properties, among others, as well as its ability to form hydrogels under the influence of a wide variety of mechanisms (thermal, ionic, pH, covalent, etc.). Its poor solubility at physiological pH, which has traditionally restricted its use, represents, on the contrary, the simplest way to induce chitosan gelation. Accordingly, herein a NaOH strong base was employed as gelling media for the direct 3D printing of chitosan structures. The obtained hydrogels were characterized in terms of morphology, chemical interactions, swelling and mechanical and rheological properties in order to evaluate the influence of the gelling solution’s ionic strength on the hydrogel characteristics. Further, the influence of printing parameters, such as extrusion speed (300, 600 and 800 mm/min) and pressure (20–35 kPa) and the cytocompatibility were also analyzed. In addition, printed gels show an electro-induced motion due to their polycationic nature, which highlights their potential as soft actuators and active scaffolds. | es_ES |
dc.description.sponsorship | This research was funded by Spanish State Research Agency (AEI) and the European Regional Development Fund (ERFD) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033, as well as the Basque Government Industry Department under the ELKARTEK programme (KK-2021/00040 and KK-2021/00082). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | chitosan | es_ES |
dc.subject | 3D printing | es_ES |
dc.subject | hydrogels | es_ES |
dc.title | pH-Induced 3D Printable Chitosan Hydrogels for Soft Actuation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-02-11T14:47:01Z | |
dc.rights.holder | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2073-4360/14/3/650 | es_ES |
dc.departamentoes | Química física | |
dc.departamentoeu | Kimika fisikoa |
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Except where otherwise noted, this item's license is described as © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).