Proportion and predictors of remission and recovery in first-episode psychosis: Systematic review and meta-analysis
dc.contributor.author | Catalán Alcántara, Ana ![]() | |
dc.contributor.author | Richter, Anja | |
dc.contributor.author | Salazar de Pablo, Gonzalo ![]() | |
dc.contributor.author | Vaquerizo Serrano, Julio | |
dc.contributor.author | Mancebo Fernández, Gonzalo | |
dc.contributor.author | Pedruzo, Borja | |
dc.contributor.author | Aymerich, Claudia | |
dc.contributor.author | Solmi, Marco | |
dc.contributor.author | González Torres, Miguel Ángel ![]() | |
dc.contributor.author | Gil López, Patxi | |
dc.contributor.author | McGuire, Philip | |
dc.contributor.author | Fusar-Poli, Paolo | |
dc.date.accessioned | 2022-02-24T10:49:39Z | |
dc.date.available | 2022-02-24T10:49:39Z | |
dc.date.issued | 2021-11 | |
dc.identifier.citation | European Psychiatry 64(1) : (2021) // Article ID e69 | es_ES |
dc.identifier.issn | 0924-9338 | |
dc.identifier.issn | 1778-3585 | |
dc.identifier.uri | http://hdl.handle.net/10810/55564 | |
dc.description.abstract | [EN] Background To determine the proportion of patients in symptomatic remission and recovery following a first-episode of psychosis (FEP). Methods A multistep literature search using the Web of Science database, Cochrane Central Register of Reviews, Ovid/PsychINFO, and trial registries from database inception to November 5, 2020, was performed. Cohort studies and randomized control trials (RCT) investigating the proportion of remission and recovery following a FEP were included. Two independent researchers searched, following PRISMA and MOOSE guidelines and using a PROSPERO protocol. We performed meta-analyses regarding the proportion of remission/recovery (symptomatic plus functional outcomes). Heterogeneity was measured employing Q statistics and I-2 test. To identify potential predictors, meta-regression analyses were conducted, as well as qualitative reporting of studies included in a systematic review. Sensitivity analyses were performed regarding different times of follow-up and type of studies. Results One hundred articles (82 cohorts and 18 RCTs) were included in the meta-analysis. The pooled proportion of symptomatic remission was 54% (95%CI [30, 49-58]) over a mean follow-up period of 43.57 months (SD = 51.82) in 76 studies. After excluding RCT from the sample, the proportion of remission remained similar (55%). The pooled proportion of recovery was 32% (95%CI [27-36]) over a mean follow-up period of 71.85 months (SD = 73.54) in 40 studies. After excluding RCT from the sample, the recovery proportion remained the same. No significant effect of any sociodemographic or clinical predictor was found. Conclusions Half of the patients are in symptomatic remission around 4 years after the FEP, while about a third show recovery after 5.5 years. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cambridge University Press | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | first-episode psychosis | es_ES |
dc.subject | predictors | es_ES |
dc.subject | psychosis | es_ES |
dc.subject | recovery | es_ES |
dc.subject | remission | es_ES |
dc.title | Proportion and predictors of remission and recovery in first-episode psychosis: Systematic review and meta-analysis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.cambridge.org/core/journals/european-psychiatry/article/proportion-and-predictors-of-remission-and-recovery-in-firstepisode-psychosis-systematic-review-and-metaanalysis/E1227C06AC918471D853EF9D85AC8C0F | es_ES |
dc.identifier.doi | 10.1192/j.eurpsy.2021.2246 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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University Press on behalf of the European
Psychiatric Association. This is an Open Access
article, distributed under the terms of the
Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.