Pathophysiology of Atherosclerosis
dc.contributor.author | Jebari Benslaiman, Shifa | |
dc.contributor.author | Galicia García, Unai | |
dc.contributor.author | Larrea Sebal, Asier | |
dc.contributor.author | Rekondo Olaetxea, Javier | |
dc.contributor.author | Alloza Moral, Iraide | |
dc.contributor.author | Vandenbroeck, Koen | |
dc.contributor.author | Benito Vicente, Asier | |
dc.contributor.author | Martín Plágaro, César Augusto | |
dc.date.accessioned | 2022-04-05T11:27:28Z | |
dc.date.available | 2022-04-05T11:27:28Z | |
dc.date.issued | 2022-03-20 | |
dc.identifier.citation | International Journal of Molecular Sciences 23(6) :(2022) // Article ID 3346 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/56198 | |
dc.description.abstract | Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel narrowing and activation of inflammatory pathways. The resultant atheroma plaque, along with these processes, results in cardiovascular complications. This review focuses on the different stages of atherosclerosis development, ranging from endothelial dysfunction to plaque rupture. In addition, the post-transcriptional regulation and modulation of atheroma plaque by microRNAs and lncRNAs, the role of microbiota, and the importance of sex as a crucial risk factor in atherosclerosis are covered here in order to provide a global view of the disease. | es_ES |
dc.description.sponsorship | This work was supported by the Basque Government (Grupos Consolidados IT-1264-19). A.B.-V. was supported by Programa de especialización de Personal Investigador Doctor en la UPV/EHU (2019) 2019/2020; U.G-G. was supported by Margarita Salas Grant; and S.J. and A.L-S were supported by a grant PIF (2017–2018) and PIF (2019–2020) Gobierno Vasco, respectively. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | atherosclerosis | es_ES |
dc.subject | endothelial dysfunction | es_ES |
dc.subject | atheroma plaque | es_ES |
dc.subject | risk factors | es_ES |
dc.subject | microbiota | es_ES |
dc.subject | ocLDL | es_ES |
dc.subject | microRNA | es_ES |
dc.subject | lncRNA | es_ES |
dc.title | Pathophysiology of Atherosclerosis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-03-24T14:47:21Z | |
dc.rights.holder | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/6/3346/htm | es_ES |
dc.identifier.doi | 10.3390/ijms23063346 | |
dc.departamentoes | Bioquímica y biología molecular | |
dc.departamentoeu | Biokimika eta biologia molekularra |
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Except where otherwise noted, this item's license is described as 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).