Is clindamycin effective in preventing infectious complications after oral surgery? Systematic review and meta-analysis of randomized controlled trials

Arteagoitia Calvo, María Iciar; Rodríguez Sánchez, Fabio; Figueras, Amaia; Arroyo-Lamas, Nagore

dc.contributor.author	Arteagoitia Calvo, María Iciar
dc.contributor.author	Rodríguez Sánchez, Fabio
dc.contributor.author	Figueras, Amaia
dc.contributor.author	Arroyo-Lamas, Nagore
dc.date.accessioned	2022-08-02T11:54:20Z
dc.date.available	2022-08-02T11:54:20Z
dc.date.issued	2022
dc.identifier.citation	Clinical Oral Investigations 26 : 4467-4478 (2022)	es_ES
dc.identifier.issn	1432-6981
dc.identifier.issn	1436-3771
dc.identifier.uri	http://hdl.handle.net/10810/57155
dc.description.abstract	[EN] Objective To determine the effect of clindamycin in the prevention of infection after oral surgery. Material and Methods This systematic review and meta-analysis followed the PRISMA statement, the PICO-framework and included only randomized controlled clinical trials. In all studies clindamycin was administered to prevent infections in patients who underwent oral surgery. Two independent researchers conducted the search, data extraction and risk of bias assessment. Included studies were classified by the type of oral surgery. Besides, data of patients, procedures and outcome variables were collected. Risk ratios (RR) and 95% confidence intervals (CI) were calculated by using Mantel-Haenszel model and the number needed to treat (NNT). Finally, any potential sources of heterogeneity were estimated. Results Seven trials of 540 articles met the inclusion criteria and were included in the qualitative synthesis. Four articles assessing the effect of oral clindamycin in third molar surgery were quantitatively analyzed. The overall RR was 0.66 (95% CI = 0.38-1.16), being non-statistically significant (p = 0.15). There was no heterogeneity between the studies I-2 = 0, p = 0.44. The NNT was 29 (95% CI = 12- -57). Conclusions The effectiveness of clindamycin could not be evaluated except in third molar extraction. Oral clindamycin is ineffective in preventing infection in third molar surgery.	es_ES
dc.description.sponsorship	Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Open Access funding provided by University of the Basque Country.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	Springer	es_ES
dc.rights	info:eu-repo/semantics/openAccess	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/es/	*
dc.subject	clindamycin	es_ES
dc.subject	infection	es_ES
dc.subject	oral surgery	es_ES
dc.subject	third molar surgery	es_ES
dc.subject	antibiotic prophylaxis	es_ES
dc.subject	systematic review	es_ES
dc.title	Is clindamycin effective in preventing infectious complications after oral surgery? Systematic review and meta-analysis of randomized controlled trials	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.rights.holder	© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.	es_ES
dc.rights.holder	Attribution 3.0 Spain	*
dc.relation.publisherversion	https://link.springer.com/article/10.1007/s00784-022-04411-2	es_ES
dc.identifier.doi	10.1007/s00784-022-04411-2
dc.departamentoes	Estomatologia I	es_ES
dc.departamentoeu	Estomatologia I	es_ES

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© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Except where otherwise noted, this item's license is described as © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.