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dc.contributor.authorGonzález Munduate, Kizkitza ORCID
dc.contributor.authorLarraza Arocena, Izaskun
dc.contributor.authorBerra, Garazi
dc.contributor.authorEceiza Mendiguren, María Aranzazu
dc.contributor.authorGabilondo López, Nagore
dc.identifier.citationInternational Journal of Pharmaceutics 622 : (2022) // Article ID 121872es_ES
dc.description.abstract[EN] Starch-based tablets with tailored releases were prepared by 3D printing using a hydrophobic drug. The importance of the origin of the excipient in the inks and tablets was analyzed. Besides, the effect of the geometry of the tablet on the drug release profile was also evaluated. The rheological properties of the inks was influenced by the botanic origin of the starch. Consequently, tablets presented different microporous structure and particular compression and swelling behaviors. Normal maize starch showed a non-well-defined porous morphology, not being able to form a stable structure whereas, waxy maize and potato starches exhibited a well-defined porous structure and were both able to maintain their integrity after long time immersion. Finally, tablets combining different starches and geometries were printed tailoring the drug release from 10 min to 6 h and designing two-steps profiles. The applicability of the developed 3D printed drug release systems in personalized therapies was demonstrated.es_ES
dc.description.sponsorshipFinancial support from the University of the Basque Country (UPV/EHU) (GIU18/216 Research Group), from the Basque Government in the frame of Elkartek KK-2020/00053 and PIBA2020-1-0041 and from Spanish Ministry of Science and Innovation and Spanish State Research Agency (MCIN/AEI/10.13039/501100011033) in the frame of PID2019-105090RB-I00 project, are gratefully acknowledged. Moreover, we are grateful to the Macrobehavior-Mesostructure-Nanotechnology SGIker unit of the UPV/EHU. K. González thanks the University of the Basque Country for the grant “Contratación de doctores recientes hasta su integración en programas de formación postdoctoral en la UPV/EHU «DOKBERRI» 2020-I” (DOCREC20/07).es_ES
dc.subject3D printinges_ES
dc.subjectoral tabletses_ES
dc.subjectcustomized drug deliveryes_ES
dc.title3D printing of customized all-starch tablets with combined release kineticses_ES
dc.rights.holder© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (
dc.rights.holderAttribution-NonCommercial-NoDerivs 3.0 Spain*
dc.departamentoesIngeniería química y del medio ambientees_ES
dc.departamentoeuIngeniaritza kimikoa eta ingurumenaren ingeniaritzaes_ES

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© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (
Except where otherwise noted, this item's license is described as © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (