dc.contributor.author | Sánchez de Alcázar Melendo, Daniel | |
dc.contributor.author | Rodríguez Abetxuko, Andoni | |
dc.contributor.author | Beloqui Elizazu, Ana | |
dc.date.accessioned | 2022-09-07T08:52:31Z | |
dc.date.available | 2022-09-07T08:52:31Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | ACS Applied Materials & Interfaces 14(24) : 27589–27598 (2022) | es_ES |
dc.identifier.issn | 1944-8244 | |
dc.identifier.issn | 1944-8252 | |
dc.identifier.uri | http://hdl.handle.net/10810/57454 | |
dc.description.abstract | [EN] A fluorometric glucose biosensor based on fine-tuned chemoenzymatic nanohybrids is herein proposed. The successful integration of an engineered glucose oxidase enzyme and an optically responsive polymeric nanogel in a single entity has led to the fabrication of a highly efficient glucose chemobiosensor. The optical responsiveness has been achieved by the loading of preactivated polymeric hydrogel with fluorescent lanthanide, i.e., cerium (III), cations. A comprehensive investigation of the responsiveness of the biomaterial revealed the interplay between the oxidation state of the cerium lanthanide and the fluorescence emission of the polymer. Finally, a full structural, chemical, and biochemical characterization of the reported system supports the chemobiosensors as robust, specific, and sensitive materials that could be utilized to faithfully quantify the amount of glucose in tear fluids. | es_ES |
dc.description.sponsorship | The authors gratefully acknowledge the financial support from the Spanish Research Agency (AEI) for the financial support (PID2019-110239RB-I00 from I+D call and RYC2018-025923-I from RyC program), including FEDER funds, IKERBASQUE-Basque Foundation for Science, and BBVA foundation (Leonardo Fellowships, IN[21] _CBB_QUI_0086). Open Access funding is provided by University of Basque Country. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RYC2018-025923-I | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-110239RB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | chemobiosensor | es_ES |
dc.subject | polymeric scaffolds | es_ES |
dc.subject | supramolecular assembly | es_ES |
dc.subject | fluorometric biosensor | es_ES |
dc.subject | smart hybrid nanomaterials | es_ES |
dc.subject | lanthanides | es_ES |
dc.title | Metal-Organic Enzyme Nanogels as Nanointegrated Self-Reporting Chemobiosensors | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 The Authors. Published by American Chemical Society.
Attribution 4.0 International (CC BY 4.0) | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://pubs.acs.org/doi/pdf/10.1021/acsami.2c04385 | es_ES |
dc.identifier.doi | 10.1021/acsami.2c04385 | |
dc.departamentoes | Química aplicada | es_ES |
dc.departamentoeu | Kimika aplikatua | es_ES |