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dc.contributor.authorErezuma, Itsasne
dc.contributor.authorLukin, Izeia
dc.contributor.authorPimenta-Lopes, Carolina
dc.contributor.authorVentura, Francesc
dc.contributor.authorGarcia-Garcia, Patricia
dc.contributor.authorReyes, Ricardo
dc.contributor.authorArnau, Mª Rosa
dc.contributor.authorDelgado, Araceli
dc.contributor.authorTaebnia, Nayere
dc.contributor.authorKadumudi, Firoz Babu
dc.contributor.authorDolatshahi-Pirouz, Alireza ORCID
dc.contributor.authorOrive Arroyo, Gorka
dc.identifier.citationInternational Journal of Pharmaceutics 623 : (2022) // Article ID 121895es_ES
dc.description.abstractBone tissue engineering has come on the scene to overcome the difficulties of the current treatment strategies. By combining biomaterials, active agents and growth factors, cells and nanomaterials, tissue engineering makes it possible to create new structures that enhance bone regeneration. Herein, hyaluronic acid and alginate were used to create biologically active hydrogels, and montmorillonite nanoclay was used to reinforce and stabilize them. The developed scaffolds were found to be biocompatible and osteogenic with mMSCs in vitro, especially those reinforced with the nanoclay, and allowed mineralization even in the absence of differentiation media. Moreover, an in vivo investigation was performed to establish the potential of the hydrogels to mend bone and act as cell-carriers and delivery platforms for SDF-1. Scaffolds embedded with SDF-1 exhibited the highest percentages of bone regeneration as well as of angiogenesis, which confirms the suitability of the scaffolds for bone. Although there are a number of obstacles to triumph over, these bioengineered structures showed potential as future bone regeneration treatments.es_ES
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Economy, Industry, and Competitiveness (PID2019-106094RB-I00/AEI/10.13039/501100011033) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country. We also appreciate the support from the Basque Country Government (Grupos Consolidados, No ref: IT907-16) . I. Erezuma and I. Lukin thank to the Basque Government for the PhD grants (PRE_2021_2_0021 & PRE_2021_2_0023) . C. Pimenta-Lopes is a recipient of a F.P.U. fellowship from the Ministry of Universidades. A.D.-P. would like to acknowledge the Danish Council for Independent Research (Technology and Production Sciences, 8105-00003B) , and the VIDI research programme with project number R0004387, which is (partly) financed by The Netherlands Organisation for Scientific Research (NWO) . This work has also received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 951747.es_ES
dc.subject3D scaffoldes_ES
dc.subjecttissue engineeringes_ES
dc.titleNanoclay-reinforced HA/alginate scaffolds as cell carriers and SDF-1 delivery-platforms for bone tissue engineeringes_ES
dc.rights.holder© 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (
dc.rights.holderAtribución 3.0 España*
dc.departamentoesFarmacia y ciencias de los alimentoses_ES
dc.departamentoeuFarmazia eta elikagaien zientziakes_ES

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© 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (
Except where otherwise noted, this item's license is described as © 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (