Cannabinoid control of hippocampal functions: thewherematters
dc.contributor.author | Robledo Menéndez, Almudena | |
dc.contributor.author | Vella, Maria | |
dc.contributor.author | Grandes Moreno, Pedro Rolando | |
dc.contributor.author | Soria Gómez, Edgar | |
dc.date.accessioned | 2022-10-10T11:09:04Z | |
dc.date.available | 2022-10-10T11:09:04Z | |
dc.date.issued | 2022-04 | |
dc.identifier.citation | FEBS Journal 289(8) : 2162-2175 (2022) | es_ES |
dc.identifier.issn | 1742-464X | |
dc.identifier.issn | 1742-4658 | |
dc.identifier.uri | http://hdl.handle.net/10810/57949 | |
dc.description.abstract | In the brain, hippocampal circuits are crucial for cognitive performance (e.g., memory) and deeply affected in pathological conditions (e.g., epilepsy, Alzheimer). Specialized molecular mechanisms regulate different cell types underlying hippocampal circuitries functions. Among them, cannabinoid receptors exhibit various roles depending on the cell type (e.g., neuron, glial cell) or subcellular organelle (e.g., mitochondria). Determining the site of action and precise mechanisms triggered by cannabinoid receptor activation at a local cellular and subcellular level helps us understand hippocampal pathophysiological states. In doing so, past and current research have advanced our knowledge of cannabinoid functions and proposed novel routes for potential therapeutics. By outlining these data in this work, we aim to showcase current findings and highlight the pathophysiological impact of the cannabinoid receptor type 1 (CB1) localization/activation in hippocampal circuits. | es_ES |
dc.description.sponsorship | This work was supported by Ikerbasque, MINECO (Ministerio de Economia y Competitividad) PGC2018-093990-A-I00 (MICIU/AEI/FEDER, UE), and Endeavour Scholarship Scheme (Malta-EU) (to E.S.-G.); Basque Government (IT1230-19), Red de Trastornos Adictivos, Instituto de Salud Carlos III (ISC-III) and European Regional Development Funds-European Union (ERDF-EU; RD16/0017/0012), Ministry of Science and Innovation (PID2019-107548RB-I00) (to P.G.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PGC2018-093990-A-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-107548RB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | astrocytes | es_ES |
dc.subject | cannabinoids | es_ES |
dc.subject | CB1 receptor | es_ES |
dc.subject | CB2 receptors | es_ES |
dc.subject | hippocampus | es_ES |
dc.subject | interneurons | es_ES |
dc.subject | memory | es_ES |
dc.subject | mitochondria | es_ES |
dc.subject | long-term depression | es_ES |
dc.subject | endocannabinoid systema | es_ES |
dc.subject | cetylcholine-release | es_ES |
dc.subject | brain | es_ES |
dc.subject | sleep | es_ES |
dc.subject | localization | es_ES |
dc.title | Cannabinoid control of hippocampal functions: thewherematters | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15907 | es_ES |
dc.identifier.doi | 10.1111/febs.15907 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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Except where otherwise noted, this item's license is described as 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of
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distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.