dc.contributor.author | Bouziane, Ismail | |
dc.contributor.author | Das, Moumita | |
dc.contributor.author | Friston, Karl J. | |
dc.contributor.author | Caballero-Gaudes, Cesar | |
dc.contributor.author | Ray, Dipanjan | |
dc.date.accessioned | 2022-10-20T09:11:54Z | |
dc.date.available | 2022-10-20T09:11:54Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Bouziane, I., Das, M., Friston, K.J. et al. Enhanced top-down sensorimotor processing in somatic anxiety. Transl Psychiatry 12, 295 (2022). https://doi.org/10.1038/s41398-022-02061-2 | es_ES |
dc.identifier.citation | Translational Psychiatry | |
dc.identifier.issn | 2158-3188 | |
dc.identifier.uri | http://hdl.handle.net/10810/58126 | |
dc.description | Published: 25 July 2022 | es_ES |
dc.description.abstract | Functional neuroimaging research on anxiety has traditionally focused on brain networks associated with the psychological aspects of anxiety. Here, instead, we target the somatic aspects of anxiety. Motivated by the growing appreciation that top-down cortical processing plays a crucial role in perception and action, we used resting-state functional MRI data from the Human Connectome Project and Dynamic Causal Modeling (DCM) to characterize effective connectivity among hierarchically organized regions in the exteroceptive, interoceptive, and motor cortices. In people with high (fear-related) somatic arousal, top-down effective connectivity was enhanced in all three networks: an observation that corroborates well with the phenomenology of anxiety. The anxiety-associated changes in connectivity were sufficiently reliable to predict whether a new participant has mild or severe somatic anxiety. Interestingly, the increase in top-down connections to sensorimotor cortex were not associated with fear affect scores, thus establishing the (relative) dissociation between somatic and cognitive dimensions of anxiety. Overall, enhanced top-down effective connectivity in sensorimotor cortices emerges as a promising and quantifiable candidate marker of trait somatic anxiety. | es_ES |
dc.description.sponsorship | This research was supported by the Basque Government through the BERC
2018–2021 program, by the Spanish Ministry of Science, Innovation, and Universities
(BCBL Severo Ochoa excellence accreditation SEV- 2015–0490 and BCAM Severo
Ochoa accreditation SEV-2017–0718), the Spanish Ministry of Economy and
Competitiveness (Ramon y Cajal Fellowship, RYC-2017–21845) and the project
MTM2017–82379- R(AEI/FEDER,UE) (principal investigator: Dr. Maria Xose Rodriguez,
BCAM). KJF was supported by funding for the Wellcome Centre for Human
Neuroimaging (Ref: 205103/Z/16/Z), a Canada-UK Artificial Intelligence Initiative (Ref:
ES/T01279X/1) and the European Union’s Horizon 2020 Framework Programme for
Research and Innovation under the Specific Grant Agreement No. 945539 (Human
Brain Project SGA3). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | SPRINGER | es_ES |
dc.relation | info:eu-repo/grantAgreement/GV/BERC2018-2021 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SEV-2015-0490 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SEV-2017-0718 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC2017-21845 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/MTM2017–82379- R | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/945539 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.title | Enhanced top-down sensorimotor processing in somatic anxiety | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © The Author(s) 2022. For the purpose of Open Access, the authors have
applied a CC BY public copyright licence to this manuscript | es_ES |
dc.relation.publisherversion | https://www.nature.com/tp/ | es_ES |
dc.identifier.doi | 10.1038/s41398-022-02061-2 | |