dc.contributor.author | Torregrosa Chinillach, Alejandro | |
dc.contributor.author | Carral Menoyo, Asier | |
dc.contributor.author | Gómez Bengoa, Enrique | |
dc.contributor.author | Chinchilla Cruz, Rafael | |
dc.date.accessioned | 2022-11-24T18:44:30Z | |
dc.date.available | 2022-11-24T18:44:30Z | |
dc.date.issued | 2022-10 | |
dc.identifier.citation | The Journal of Organic Chemistry 87(21) : 14507-14513 (2022) | es_ES |
dc.identifier.issn | 0022-3263 | |
dc.identifier.issn | 1520-6904 | |
dc.identifier.uri | http://hdl.handle.net/10810/58544 | |
dc.description.abstract | A highly efficient enantioselective alpha-nitrogenation method of alpha,alpha-disubstituted aldehydes with azodicarboxylates promoted by a chiral carbamate-monoprotected cyclohexa-1,2diamine as organocatalyst has been developed. The process was carried out without any solvent, and the corresponding alpha,alpha- disubstituted alpha-nitrogenated aldehydes were obtained with excellent yields and enantioselectivities up to 99% ee. The sustainability of the procedure was established through the calculation of green metrics, such as EcoScale and E-factor. In addition, theoretical calculations have been used to justify the obtained enantioselectivity sense. | es_ES |
dc.description.sponsorship | This work was funded by the Spanish Ministry of Economy, Industry and Competitiveness (PGC2018-096616-B-I00) , the Spanish Ministry of Science and Innovation (PID2019- 110008GB-I00) , and the University of Alicante (VIGROB- 173) . We also thank SGIker (UPV/EHU) for providing human and computational resources. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/PGC2018-096616-B-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019- 110008GB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | amino acids | es_ES |
dc.subject | amination | es_ES |
dc.subject | construction | es_ES |
dc.subject | catalysis | es_ES |
dc.subject | design | es_ES |
dc.title | Organocatalytic Enantioselective alpha-Nitrogenation of alpha,alpha- Disubstituted Aldehydes in the Absence of a Solvent | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 The Authors. Published by American Chemical Society. Attribution 4.0 International (CC BY 4.0) | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acs.joc.2c01919 | es_ES |
dc.identifier.doi | 10.1021/acs.joc.2c01919 | |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |