Show simple item record

dc.contributor.authorNzioka, Anthony
dc.contributor.authorValencia López, Ainara
dc.contributor.authorAtxaerandio Landa, Aitor
dc.contributor.authorDiaz de Cerio Arruabarrena, Oihane ORCID
dc.contributor.authorHossain, Mohammad Amzad
dc.contributor.authorKorta, María
dc.contributor.authorOrtiz Zarragoitia, Maren
dc.contributor.authorCancio Uriarte, Ibon ORCID
dc.identifier.citationMarine Environmental Research 183 : (2023) // Article ID 105846es_ES
dc.description.abstractFollicular atresia is an energy-saving oocyte resorption process that can allow the survival of female fish when environmental conditions are unfavourable and at the expense of fecundity. This study investigated the transcription levels of apoptosis and autophagy-related genes during atresia in the European hake that can show episodes of increased follicular atresia throughout the reproductive cycle. 169 female individuals were collected from the Bay of Biscay, and the ovaries were analysed using histological and molecular methods. Different levels of atresia were histologically detected in 73.7% of the ovaries analysed and the TUNEL assay identified apoptotic nuclei in follicles from both previtellogenic and vitellogenic stages. Transcripts of beclin-1 and ptenb were up-regulated in the ovaries containing atretic follicles, whereas p53, caspase-3, cathepsin D and dapk1 were up-regulated only in ovaries presenting vitellogenic atretic follicles. Our results indicate different implications of apoptotic vs autophagic processes leading to atresia during oocyte development, vitellogenesis being the moment of maximal apoptotic and autophagic activity in atretic hakes. The analysed genes could provide early warning biomarkers to identify follicular atresia in fish and evaluate fecundity in fish stocks.es_ES
dc.description.sponsorshipThis work was funded by the Spanish Ministry of Science, Innovation and Universities (ATREoVO AGL2015-63936-R and BORN2bEGG PGC2018-101442-B-I00) and by the Basque Government (Grant to consolidated research groups IT1302-19). A.N. is a recipient of a pre-doctoral grant from the University of the Basque Country (UPV/EHU). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.subjectEuropean hakees_ES
dc.subjectfollicular atresiaes_ES
dc.subjectreproductive cyclemes_ES
dc.titleApoptosis and autophagy-related gene transcription during ovarian follicular atresia in European hake (Merluccius merluccius).es_ES
dc.rights.holder© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ( nc-nd/4.0/).es_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas 3.0 España*
dc.departamentoesInmunología, microbiología y parasitologíaes_ES
dc.departamentoesZoología y biología celular animales_ES
dc.departamentoeuImmunologia, mikrobiologia eta parasitologiaes_ES
dc.departamentoeuZoologia eta animalia zelulen biologiaes_ES

Files in this item


This item appears in the following Collection(s)

Show simple item record

© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
Except where otherwise noted, this item's license is described as © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ( nc-nd/4.0/).