dc.contributor.author | García Arnáez, Iñaki | |
dc.contributor.author | Cerqueira, Andreia | |
dc.contributor.author | Romero Gavilán, Francisco | |
dc.contributor.author | Elortza, Felix | |
dc.contributor.author | Azkargorta, Mikel | |
dc.contributor.author | Iloro, Ibon | |
dc.contributor.author | Suay, Julio | |
dc.contributor.author | Goñi Echave, Isabel María del Coro | |
dc.contributor.author | Gurruchaga Torrecilla, María Dolores | |
dc.date.accessioned | 2023-01-20T18:04:18Z | |
dc.date.available | 2023-01-20T18:04:18Z | |
dc.date.issued | 2022-12 | |
dc.identifier.citation | Materials Today Communications 33 : (2022) // Article ID 104674 | es_ES |
dc.identifier.issn | 2352-4928 | |
dc.identifier.uri | http://hdl.handle.net/10810/59392 | |
dc.description.abstract | Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of os-teoblasts and inhibits the activity of osteoclasts. Our principal objective in this study was to formulate new organic-inorganic hybrid sol-gel coatings applied to titanium discs. These coatings were functionalised with different amounts of SrCl2 and examined using in vitro tests and proteomics. The chemical and morphological characteristics of obtained coatings were scrutinised. The in vitro evaluation using the MC3T3-E1 osteoblasts and RAW264.7 macrophages showed the osteogenic and anti-inflammatory effects of strontium doping. The prote-omic assay identified 111 different proteins adhering to the coatings. Six of these proteins reduced their adhesion affinity as a result of Sr-doping, whereas 40 showed increased affinity. Moreover, the proteomic analysis revealed osteogenic and anti-inflammatory properties of these biomaterials. The analysis also showed increased adhesion of proteins related to the coagulation system. We can conclude that proteomic methods are invaluable in developing new biomaterials and represent an important tool for predicting the biocompatibility of dental implants. | es_ES |
dc.description.sponsorship | The work was supported by MICIU [RTC-2017-6147-1], MINECO [PID2020-113092RB-C21], Generalitat Valenciana [APOSTD/2020/036, PROMETEO/2020/069], Basque Government [PRE_2016_1_0141] and Universitat Jaume I [UJI-B2021-25]. The authors would like to thank the company GMI-Ilerimplant for producing the titanium discs. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RTC-2017-6147-1 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2020-113092RB-C21 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | dental implants | es_ES |
dc.subject | proteomics | es_ES |
dc.subject | osteogenesis | es_ES |
dc.subject | biomedical applications | es_ES |
dc.subject | bone regeneration | es_ES |
dc.title | Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-
nc-nd/4.0/) | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S235249282201515X?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.mtcomm.2022.104674 | |
dc.departamentoes | Polímeros y Materiales Avanzados: Física, Química y Tecnología | es_ES |
dc.departamentoeu | Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia | es_ES |