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Raman Spectroscopy as a Tool to Study the Pathophysiology of Brain Diseases

dc.contributor.authorTerrones Urio, Oihana ORCID
dc.contributor.authorOlazar Intxausti, June
dc.contributor.authorAnso, Itxaso
dc.contributor.authorLorizate Nogales, Maier
dc.contributor.authorNieto Garai, Jon Ander
dc.contributor.authorContreras, F. Xabier
dc.date.accessioned2023-02-13T17:12:50Z
dc.date.available2023-02-13T17:12:50Z
dc.date.issued2023-01-25
dc.identifier.citationInternational Journal of Molecular Sciences 24(3) : (2023) // Article ID 2384es_ES
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10810/59786
dc.description.abstractThe Raman phenomenon is based on the spontaneous inelastic scattering of light, which depends on the molecular characteristics of the dispersant. Therefore, Raman spectroscopy and imaging allow us to obtain direct information, in a label-free manner, from the chemical composition of the sample. Since it is well established that the development of many brain diseases is associated with biochemical alterations of the affected tissue, Raman spectroscopy and imaging have emerged as promising tools for the diagnosis of ailments. A combination of Raman spectroscopy and/or imaging with tagged molecules could also help in drug delivery and tracing for treatment of brain diseases. In this review, we first describe the basics of the Raman phenomenon and spectroscopy. Then, we delve into the Raman spectroscopy and imaging modes and the Raman-compatible tags. Finally, we center on the application of Raman in the study, diagnosis, and treatment of brain diseases, by focusing on traumatic brain injury and ischemia, neurodegenerative disorders, and brain cancer.es_ES
dc.description.sponsorshipThe APC was funded by grant PID2020-117405GB100, funded by MCIN/AEI/10.13039/501100011033 and, as appropriate, by “ERDF A way of making Europe” by the “European Union” or by the “European Union NextGenerationEU/PRTR”; by the Basque Government, grant numbers ELKARTEK22/86 and IT1625-22; and by Fundación Ramón Areces, grant number CIVP20S11276.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2020-117405GB100es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectRaman spectroscopyes_ES
dc.subjectSERSes_ES
dc.subjectCARSes_ES
dc.subjectbraines_ES
dc.subjecttraumatic brain injuryes_ES
dc.subjectcanceres_ES
dc.subjectneurodegenerative diseasees_ES
dc.subjectAlzheimer’s diseasees_ES
dc.subjectParkinson’s diseasees_ES
dc.titleRaman Spectroscopy as a Tool to Study the Pathophysiology of Brain Diseaseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2023-02-10T14:28:55Z
dc.rights.holder© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/24/3/2384es_ES
dc.identifier.doi10.3390/ijms24032384
dc.departamentoesBioquímica y biología molecular
dc.departamentoeuBiokimika eta biologia molekularra


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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).
Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).