The Role of α-Synuclein in the Regulation of Serotonin System: Physiological and Pathological Features
dc.contributor.author | Miquel Rio, Lluis | |
dc.contributor.author | Sarriés Serrano, Unai | |
dc.contributor.author | Pavía Collado, Rubén | |
dc.contributor.author | Meana Martínez, José Javier ![]() | |
dc.contributor.author | Bortolozzi, Analia | |
dc.date.accessioned | 2023-02-27T17:14:20Z | |
dc.date.available | 2023-02-27T17:14:20Z | |
dc.date.issued | 2023-02-13 | |
dc.identifier.citation | Biomedicines 11(2) : (2023) // Article ID 541 | es_ES |
dc.identifier.issn | 2227-9059 | |
dc.identifier.uri | http://hdl.handle.net/10810/60134 | |
dc.description.abstract | In patients affected by Parkinson’s disease (PD), up to 50% of them experience cognitive changes, and psychiatric disturbances, such as anxiety and depression, often precede the onset of motor symptoms and have a negative impact on their quality of life. Pathologically, PD is characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and the presence of intracellular inclusions, called Lewy bodies and Lewy neurites, composed mostly of α-synuclein (α-Syn). Much of PD research has focused on the role of α-Syn aggregates in the degeneration of SNc DA neurons due to the impact of striatal DA deficits on classical motor phenotypes. However, abundant Lewy pathology is also found in other brain regions including the midbrain raphe nuclei, which may contribute to non-motor symptoms. Indeed, dysfunction of the serotonergic (5-HT) system, which regulates mood and emotional pathways, occurs during the premotor phase of PD. However, little is known about the functional consequences of α-Syn inclusions in this neuronal population other than DA neurons. Here, we provide an overview of the current knowledge of α-Syn and its role in regulating the 5-HT function in health and disease. Understanding the relative contributions to α-Syn-linked alterations in the 5-HT system may provide a basis for identifying PD patients at risk for developing depression and could lead to a more targeted therapeutic approach. | es_ES |
dc.description.sponsorship | This research was funded by grants PID2019-105136RB-100, MCIN/AEI/10.13039/501100011033 and ERDF A way of making Europe, by the Euro-pean Union, and CB/07/09/0034 and CB/07/09/0008 Center for Networked Biomedical Research on Mental Health (CIBERSAM). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-105136RB-100 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | depression | es_ES |
dc.subject | Parkinson’s disease | es_ES |
dc.subject | α-synuclein | es_ES |
dc.subject | serotonin | es_ES |
dc.subject | raphe nuclei | es_ES |
dc.title | The Role of α-Synuclein in the Regulation of Serotonin System: Physiological and Pathological Features | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-02-24T14:08:10Z | |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2227-9059/11/2/541 | es_ES |
dc.identifier.doi | 10.3390/biomedicines11020541 | |
dc.departamentoes | Farmacología | |
dc.departamentoeu | Farmakologia |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).