dc.contributor.author | Catalán Alcántara, Ana | |
dc.contributor.author | EU-GEI High-Risk Study Group | |
dc.date.accessioned | 2023-03-21T16:35:54Z | |
dc.date.available | 2023-03-21T16:35:54Z | |
dc.date.issued | 2023-03 | |
dc.identifier.citation | Schizophrenia Bulletin 49(2) : 339-349 (2023) | es_ES |
dc.identifier.issn | 0586-7614 | |
dc.identifier.issn | 1745-1701 | |
dc.identifier.uri | http://hdl.handle.net/10810/60430 | |
dc.description.abstract | Background and hypothesis
Around 20% of people at clinical high risk (CHR) for psychosis later develop a psychotic disorder, but it is difficult to predict who this will be. We assessed the incidence of hearing speech (termed speech illusions [SIs]) in noise in CHR participants and examined whether this was associated with adverse clinical outcomes.
Study design
At baseline, 344 CHR participants and 67 healthy controls were presented with a computerized white noise task and asked whether they heard speech, and whether speech was neutral, affective, or whether they were uncertain about its valence. After 2 years, we assessed whether participants transitioned to psychosis, or remitted from the CHR state, and their functioning.
Study results
CHR participants had a lower sensitivity to the task. Logistic regression revealed that a bias towards hearing targets in stimuli was associated with remission status (OR = 0.21, P = 042). Conversely, hearing SIs with uncertain valence at baseline was associated with reduced likelihood of remission (OR = 7.72. P = .007). When we assessed only participants who did not take antipsychotic medication at baseline, the association between hearing SIs with uncertain valence at baseline and remission likelihood remained (OR = 7.61, P = .043) and this variable was additionally associated with a greater likelihood of transition to psychosis (OR = 5.34, P = .029).
Conclusions
In CHR individuals, a tendency to hear speech in noise, and uncertainty about the affective valence of this speech, is associated with adverse outcomes. This task could be used in a battery of cognitive markers to stratify CHR participants according to subsequent outcomes. | es_ES |
dc.description.sponsorship | The European Network of National Schizophrenia Networks Studying Gene Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2- 2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme. Additional support was provided by a Medical Research Council Fellowship to M Kempton (grant MR/J008915/1), and by the Ministerio de Ciencia, Innovación e Universidades to N Barrantes-Vidal (project PSI2017-87512-C2-1-R). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/241909 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PSI2017-87512-C2-1-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | signal-detection | es_ES |
dc.subject | white noise task | es_ES |
dc.subject | uncertainty | es_ES |
dc.subject | remission | es_ES |
dc.subject | transition | es_ES |
dc.title | Speech Illusions in People at Clinical High Risk for Psychosis Linked to Clinical Outcome | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022, Oxford University Press. This article is available under the Creative Commons CC-BY-NC license and permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://academic.oup.com/schizophreniabulletin/article/49/2/339/6901995?login=true | es_ES |
dc.identifier.doi | 10.1093/schbul/sbac163 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |