Nanocarriers for Skin Applications: Where Do We Stand?
dc.contributor.author | Tiwari, Neha | |
dc.contributor.author | Osorio Blanco, Ernesto Rafael | |
dc.contributor.author | Sonzogni, Ana | |
dc.contributor.author | Esporrín Ubieto, David | |
dc.contributor.author | Wang, Huiyi | |
dc.contributor.author | Calderón, Marcelo | |
dc.date.accessioned | 2023-03-22T16:32:50Z | |
dc.date.available | 2023-03-22T16:32:50Z | |
dc.date.issued | 2022-01 | |
dc.identifier.citation | Angewandte Chemie International Edition 61(3) : (2022) // Article ID e202107960 | es_ES |
dc.identifier.issn | 1433-7851 | |
dc.identifier.issn | 1521-3773 | |
dc.identifier.uri | http://hdl.handle.net/10810/60450 | |
dc.description.abstract | Skin penetration of active molecules for treatment of diverse diseases is a major field of research owing to the advantages associated with the skin like easy accessibility, reduced systemic-derived side effects, and increased therapeutic efficacy. Despite these advantages, dermal drug delivery is generally challenging due to the low skin permeability of therapeutics. Although various methods have been developed to improve skin penetration and permeation of therapeutics, they are usually aggressive and could lead to irreversible damage to the stratum corneum. Nanosized carrier systems represent an alternative approach for current technologies, with minimal damage to the natural barrier function of skin. In this Review, the use of nanoparticles to deliver drug molecules, genetic material, and vaccines into the skin is discussed. In addition, nanotoxicology studies and the recent clinical development of nanoparticles are highlighted to shed light on their potential to undergo market translation. | es_ES |
dc.description.sponsorship | We are grateful to Maria Angela Motta and Oliver Etzold for their valuable scientific inputs and corrections in the review. We are thankful to MINECO (RTI2018-098951-B-I00), IKERBASQUE-Basque Foundation for Science, Basque Government (Elkartek projects KK-2019/00086 and KK2020/00010; proyectos de investigacion basica/aplicada PIBA_2020_1_0056), Gipuzkoa Provincial Council (2019CIEN-000075-01), and to Polymat, Basque Centre for Macromolecular Design and Engineering for funding. A.S. acknowledges financial support from CONICET, ANPCyT, Universidad Nacional del Litoral. H.W. is thankful for the financial support received from China Scholarship Council (File no. 201804910606). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RTI2018-098951-B-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | drug delivery | es_ES |
dc.subject | gene expression | es_ES |
dc.subject | nanoparticles | es_ES |
dc.subject | skin penetration | es_ES |
dc.subject | transdermal vaccination | es_ES |
dc.title | Nanocarriers for Skin Applications: Where Do We Stand? | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/anie.202107960 | es_ES |
dc.identifier.doi | 10.1002/anie.202107960 |
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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.