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dc.contributor.authorRodríguez Fuentes, Manuel Eros
dc.contributor.authorPérez Sayáns, Mario
dc.contributor.authorMartín Carreras-Presas, Carmen
dc.contributor.authorMarichalar Mendia, Xabier
dc.contributor.authorBagán Debón, Leticia
dc.contributor.authorLópez López, Rafael
dc.date.accessioned2023-03-23T16:21:23Z
dc.date.available2023-03-23T16:21:23Z
dc.date.issued2023-03
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 135(3) : 385-395 (2023)es_ES
dc.identifier.issn2212-4411
dc.identifier.urihttp://hdl.handle.net/10810/60467
dc.description.abstractOBJECTIVE: The aim of this study was to determine the prevalence of acute oral mucosal toxicities in non-irradiated patients treated with systemic antineoplastics agents. The secondary objective was to find out differences in its prevalence among the different types of systemic antineoplastics. STUDY DESIGN: A systematic review and meta-analysis was performed. Articles from 2010 to July 2022 were retrieved and included if patients were adults undergoing oral assessment after administration of commercially available systemic antineoplastics. Data was extracted and pooled proportions were estimated using random-effect model method (Der Simonian and Lair). RESULTS: Eighty-two articles were included in the study. The overall prevalence of acute oral mucosal damage across studies was 38.2% (95% CI: 33.1%-43.3%). The prevalence was 42.9% (95% CI: 32.8%-53%) in patients treated with chemotherapy alone, 38% (95% CI: 29.1%-47%) in patients treated with a combination of chemotherapy and targeted therapies, and 32.1% (95% CI: 26.8%-37.5%) in targeted therapies alone-treated patients. No statistically significant differences were found in the prevalence of oral mucosal toxicities between the different types of systemic antineoplastic treatments. CONCLUSIONS: Oral mucosal toxicity is a major side effect in non-irradiated cancer patients undergoing systemic antineoplastics.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titlePrevalence of acute oral mucosal damage secondary to the use of systemic antineoplastics: A systematic review and meta-analysises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/)es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2212440322012883?via%3Dihubes_ES
dc.identifier.doi10.1016/j.oooo.2022.11.016
dc.departamentoesEnfermeríaes_ES
dc.departamentoeuErizaintzaes_ES


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© 2022 The Author(s). Published by Elsevier Inc. This is an open
access article under the CC BY license (http://creativecommons.org/
licenses/by/4.0/)
Except where otherwise noted, this item's license is described as © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/)