Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study
dc.contributor.author | Prieto Botella, Daniel | |
dc.contributor.author | Martens, Dries S. | |
dc.contributor.author | Valera Gran, Desirée | |
dc.contributor.author | Subiza Pérez, Mikel | |
dc.contributor.author | Tardón, Adonina | |
dc.contributor.author | Lozano, Manuel | |
dc.contributor.author | Casas, Maribel | |
dc.contributor.author | Bustamante, Mariona | |
dc.contributor.author | Jimeno Romero, Alba | |
dc.contributor.author | Fernández Somoano, Ana | |
dc.contributor.author | Llop, Sabrina | |
dc.contributor.author | Vrijheid, Martine | |
dc.contributor.author | Nawrot, Tim S. | |
dc.contributor.author | Navarrete Muñoz, Eva María | |
dc.date.accessioned | 2023-03-31T13:22:06Z | |
dc.date.available | 2023-03-31T13:22:06Z | |
dc.date.issued | 2023-03-14 | |
dc.identifier.citation | International Journal of Environmental Research and Public Health 20(6) : (2023) // Article ID 5134 | es_ES |
dc.identifier.issn | 1660-4601 | |
dc.identifier.uri | http://hdl.handle.net/10810/60581 | |
dc.description.abstract | Sedentary behaviour (SB) may be related to telomere length (TL) attrition due to a possible pro-inflammatory effect. This study examined the association between parent-reported sedentary behaviour (SB) and leukocyte TL at the age of 4 and telomere tracking from 4 to 8 years. In the Spanish birth cohort Infancia y Medio Ambiente (INMA) project, we analysed data from children who attended follow-up visits at age 4 (n = 669) and 8 (n = 530). Multiple robust regression models were used to explore the associations between mean daily hours of SB (screen time, other sedentary activities, and total SB) at 4 years categorised into tertiles and TL at 4 years and difference in TL rank between age 4 and 8, respectively. At the age of 4, the results showed that children with the highest screen time (1.6–5.0 h/day) had a shorter TL of −3.9% (95% CI: −7.4, −0.4; p = 0.03) compared with children in the lowest tertile (0.0–1.0 h/day). Between 4 and 8 years, a higher screen time (highest tertile group vs. lowest tertile) was associated with a decrease in the LTL rank of −1.9% (95% CI: −3.8, −0.1; p = 0.03) from 4 to 8 years. Children exposed to a higher screen time at 4 years were more prone to have shorter TL at 4 and between 4 and 8 years of age. This study supports the potential negative effect of SB during childhood on cellular longevity. | es_ES |
dc.description.sponsorship | This research was funded by the Instituto de Salud Carlos III/Agencia Estatal de Investigación (PI18/00825: “Dieta y actividad física en embarazo y tras el nacimiento y longitud del telómero en niños y adolescentes: Proyecto TeloDiPA” and European Regional Development Fund (ERDF): “Una manera de hacer Europa”); the Generalitat Valenciana (GVA/2021/191, CIAICO/2021/132); the Instituto de Salud Carlos III (FIS-PI09/00090, PI04/2018, PI09/02311, PI13/02429, PI16/1288, PI18/00909, PI19/1338 and FIS-PI18/01142 incl. ERFD funds, PS20/0006), the Department of Health of the Basque Government (2013111089); the Instituto de Salud Carlos III (FIS-PI13/02187 and FIS-PI18/01142 incl. ERFD funds), the Department of Health of the Basque Government (2015111065), and the Provincial Government of Gipuzkoa (DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain); Obra Social Cajastur/Fundación Liberbank and Universidad de Oviedo; and Gobierno de España through Ministerio de Universidades under the grants CAS21/00008 and NextGenerationEU. DPB was supported by the Miguel Hernández University (Ayudas Movilidad Internacional 2021, Erasmus+ 2021) during the development of this study. In addition, DM holds a postdoctoral grant by the Flemish Scientific Fund (FWO grant 12X9620N). The funders had no role in the design of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval and submission of the manuscript. The APC was funded by PI18/00825. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | lifestyle | es_ES |
dc.subject | children | es_ES |
dc.subject | genetics | es_ES |
dc.subject | screen time | es_ES |
dc.subject | epigenetics | es_ES |
dc.subject | cellular longevity | es_ES |
dc.title | Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-03-28T12:56:34Z | |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1660-4601/20/6/5134 | es_ES |
dc.identifier.doi | 10.3390/ijerph20065134 | |
dc.departamentoes | Psicología Clínica y de la Salud y Metodología de Investigación | |
dc.departamentoeu | Psikologia Klinikoa eta Osasunaren Psikologia eta Ikerketa Metodologia |
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Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).