dc.contributor.author | Polo Arroyabe, Yurena | |
dc.contributor.author | Luzuriaga González, Jon | |
dc.contributor.author | González de Langarica, Sergio | |
dc.contributor.author | Pardo Rodríguez, Beatriz | |
dc.contributor.author | Martínez Tong, Daniel Enrique | |
dc.contributor.author | Tapeinos, Christos | |
dc.contributor.author | Manero Roig, Irene | |
dc.contributor.author | Marín, Edurne | |
dc.contributor.author | Muñoz Ugartemendia, Jone | |
dc.contributor.author | Ciofani, Gianni | |
dc.contributor.author | Ibarretxe Bilbao, Gaskon | |
dc.contributor.author | Unda Rodríguez, Fernando José | |
dc.contributor.author | Sarasua Oiz, José Ramón | |
dc.contributor.author | Pineda Martí, José Ramón | |
dc.contributor.author | Larrañaga Espartero, Aitor | |
dc.date.accessioned | 2023-04-24T17:38:35Z | |
dc.date.available | 2023-04-24T17:38:35Z | |
dc.date.issued | 2023-03 | |
dc.identifier.citation | Nanoscale 15(9) : 4488-4505 (2023) | es_ES |
dc.identifier.issn | 2040-3364 | |
dc.identifier.issn | 2040-3372 | |
dc.identifier.uri | http://hdl.handle.net/10810/60919 | |
dc.description.abstract | Stem cell-based therapies have shown promising results for the regeneration of the nervous system. However, the survival and integration of the stem cells in the neural circuitry is suboptimal and might compromise the therapeutic outcomes of this approach. The development of functional scaffolds capable of actively interacting with stem cells may overcome the current limitations of stem cell-based therapies. In this study, three-dimensional hydrogels based on graphene derivatives and cerium oxide (CeO2) nanoparticles are presented as prospective supports allowing neural stem cell adhesion, migration and differentiation. The morphological, mechanical and electrical properties of the resulting hydrogels can be finely tuned by controlling several parameters of the self-assembly of graphene oxide sheets, namely the amount of incorporated reducing agent (ascorbic acid) and CeO2 nanoparticles. The intrinsic properties of the hydrogels, as well as the presence of CeO2 nanoparticles, clearly influence the cell fate. Thus, stiffer adhesion substrates promote differentiation to glial cell lineages, while softer substrates enhance mature neuronal differentiation. Remarkably, CeO2 nanoparticle-containing hydrogels support the differentiation of neural stem cells to neuronal, astroglial and oligodendroglial lineage cells, promoting the in vitro generation of nerve tissue grafts that might be employed in neuroregenerative cell therapies. | es_ES |
dc.description.sponsorship | This work has been funded by the Basque Government (GV/EJ) Department of Education (GIC21/131 IT1766-22, IT1751-22), Health Department (RIS3, 2021333012), Grants PID2019-106236GB-I00 and PID2019-104766RB-C21 funded by MCIN/AEI/10.13039/501100011033. Grant RYC-2013-13450 funded by MCIN/AEI/10.13039/501100011033 and by "ESF investing in your future" by the "European Union" and Achucarro Seed-Fund 003 (JRP), the University of the Basque Country (UPV/EHU) by GIU19/040, GIU 20/050, PPGA 20/22, COLAB19/03 and IKERTU-2020.0155. GV/EJ, Hazitek ZE-2019/00012-IMABI and ELKARTEK KK-2019/00093. Polimerbio and Y. P. have a Bikaintek PhD grant (20-AFW2-2018-00001). Part of this research was performed within the framework of the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement No. 793644 (BIONICS). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/793644 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-106236GB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-104766RB-C21 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC-2013-13450 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.title | Self-assembled three-dimensional hydrogels based on graphene derivatives and cerium oxide nanoparticles: scaffolds for co-culture of oligodendrocytes and neurons derived from neural stem cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2023/NR/D2NR06545B | es_ES |
dc.identifier.doi | 10.1039/d2nr06545b | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoes | Fisiología | es_ES |
dc.departamentoes | Ingeniería Minera y Metalúrgica y Ciencia de los Materiales | es_ES |
dc.departamentoeu | Fisiologia | es_ES |
dc.departamentoeu | Meatze eta metalurgia ingeniaritza materialen zientzia | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |