Tumour-derived extracellular vesicle based vaccines for melanoma treatment

González Melero, Lorena; Hernández Martín, Rosa María; Santos Vizcaíno, Edorta; Igartua Olaechea, Manuela

dc.contributor.author	González Melero, Lorena
dc.contributor.author	Hernández Martín, Rosa María
dc.contributor.author	Santos Vizcaíno, Edorta
dc.contributor.author	Igartua Olaechea, Manuela
dc.date.accessioned	2023-05-11T17:01:37Z
dc.date.available	2023-05-11T17:01:37Z
dc.date.issued	2023-05
dc.identifier.citation	Drug Delivery and Translational Research 13(5) : 1520-1542 (2023)	es_ES
dc.identifier.issn	2190-393X
dc.identifier.issn	2190-3948
dc.identifier.uri	http://hdl.handle.net/10810/61087
dc.description.abstract	The interest of extracellular vesicles (EVs) in cancer immunotherapy is increasing every day. EVs are lipid bilayer vesicles released by most cells, which contain the molecular signature of their parent cell. Melanoma-derived EVs present antigens specific to this aggressive type of cancer, but they also exert immunomodulatory and pro- metastatic activity. Until now, most reviews focus on the immunoevasive characteristics of tumour-derived EVs, but do not help to overcome the issues related to them. In this review, we describe isolation methods of EVs from melanoma patients and most interesting markers to oversee their effect if they are used as antigen carriers. We also discuss the methods developed so far to overcome the lack of immunogenicity of melanoma-derived EVs, which includes EV modification or adjuvant co-administration. In summary, we conclude that EVs can be an interesting antigen source for immunotherapy development once EV obtaining is optimised and the understanding of the mechanisms behind their multiple effects is further understood.	es_ES
dc.description.sponsorship	Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the Basque Government (ELKARTEK project ONKOtools (KK20/00069), ONKOVAC (2021111042), and Consolidated Groups, IT1448-22). Lorena Gonzalez-Melero thanks the University of the Basque Country (UPV/EHU) for the PhD grant (PIF18-295).	es_ES
dc.language.iso	eng	es_ES
dc.publisher	Springer	es_ES
dc.rights	info:eu-repo/semantics/openAccess	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/es/	*
dc.subject	melanoma	es_ES
dc.subject	extracellular vesicles	es_ES
dc.subject	exosomes	es_ES
dc.subject	immunotherapy	es_ES
dc.subject	immunostimulatory molecules	es_ES
dc.subject	tumour cells	es_ES
dc.title	Tumour-derived extracellular vesicle based vaccines for melanoma treatment	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.rights.holder	© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.	es_ES
dc.rights.holder	Atribución 3.0 España	*
dc.relation.publisherversion	https://link.springer.com/article/10.1007/s13346-023-01328-5	es_ES
dc.identifier.doi	10.1007/s13346-023-01328-5
dc.departamentoes	Farmacia y ciencias de los alimentos	es_ES
dc.departamentoeu	Farmazia eta elikagaien zientziak	es_ES

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© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Except where otherwise noted, this item's license is described as © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.