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Photosensitizer-Mesoporous Silica Nanoparticles Combination for Enhanced Photodynamic Therapy

dc.contributor.authorPrieto Montero, Ruth
dc.contributor.authorArbeloa López, María Teresa ORCID
dc.contributor.authorMartínez Martínez, Virginia ORCID
dc.date.accessioned2023-07-03T16:57:42Z
dc.date.available2023-07-03T16:57:42Z
dc.date.issued2023-05
dc.identifier.citationPhotochemistry and Photobiology 99(3) : 882-900 (2023)es_ES
dc.identifier.issn0031-8655
dc.identifier.issn1751-1097
dc.identifier.urihttp://hdl.handle.net/10810/61862
dc.description.abstractMesoporous silica nanoparticles (MSNs) are widely known for their versatile applications. One of the most extended is as drug delivery systems for the treatment of cancer and other diseases. This review compiles the most representative examples in the last years of functionalized MSNs as photosensitizer carriers for photodynamic therapy (PDT) against cancer. Several commercially available photosensitizers (PSs) demonstrated poor solubility in an aqueous medium and insufficient selectivity for cancer tissues. The tumor specificity of PSs is a key factor for enhancing the PDT effect and at the same time reducing side effects. The use of nanoparticles and particularly MSNs, in which PS is covalently anchored or physically embedded, can overcome these limitations. For that, PS-MSNs can be externally decorated with compounds of interest in order to act as an active target for certain cancer cells, demonstrating enhanced phototoxicity in vitro and in vivo. The objective of this review is to collect and compare different nanosystems based on PS-MSNs pointing out their advantages in PDT against diverse types of cancers.es_ES
dc.description.sponsorshipWe gratefully acknowledge financial support from MCIN/AEI/10.13039/501100011033 (project PID2020-114347RB-C32), and Gobierno Vasco-Eusko Jaurlaritza (project IT1639-22). R.P.-M. thanks UPV/EHU, MIU and NGEU for their postdoctoral contract (MARSA21/71).es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/ PID2020-114347RB-C32es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titlePhotosensitizer-Mesoporous Silica Nanoparticles Combination for Enhanced Photodynamic Therapyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2023 The Authors. Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/php.13802?af=Res_ES
dc.identifier.doi10.1111/php.13802
dc.departamentoesQuímica físicaes_ES
dc.departamentoeuKimika fisikoaes_ES


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© 2023 The Authors. Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as © 2023 The Authors. Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.