Synthesis of Aminoalkyl Sclareolide Derivatives and Antifungal Activity Studies
dc.contributor.author | Li, Ziyi | |
dc.contributor.author | Gao, Hua | |
dc.contributor.author | Mei, Haibo | |
dc.contributor.author | Wu, Guangwei | |
dc.contributor.author | Soloshonok, Vadym Anatolievch | |
dc.contributor.author | Han, Jianlin | |
dc.date.accessioned | 2023-09-25T14:35:53Z | |
dc.date.available | 2023-09-25T14:35:53Z | |
dc.date.issued | 2023-05-12 | |
dc.identifier.citation | Molecules 28(10) : (2023) // Article ID 4067 | es_ES |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | http://hdl.handle.net/10810/62666 | |
dc.description.abstract | Sclareolide was developed as an efficient C-nucleophilic reagent for an asymmetric Mannich addition reaction with a series of N-tert-butylsulfinyl aldimines. The Mannich reaction was carried out under mild conditions, affording the corresponding aminoalkyl sclareolide derivatives with up to 98% yield and 98:2:0:0 diastereoselectivity. Furthermore, the reaction could be performed on a gram scale without any reduction in yield and diastereoselectivity. Additionally, deprotection of the obtained Mannich addition products to give the target sclareolide derivatives bearing a free N-H group was demonstrated. In addition, target compounds 4–6 were subjected to an antifungal assay in vitro, which showed considerable antifungal activity against forest pathogenic fungi. | es_ES |
dc.description.sponsorship | Financial support from the National Natural Science Foundation of China (Nos. 21761132021 and 21606133) and IKERBASQUE, Basque Foundation for Science. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | sclareolide | es_ES |
dc.subject | Mannich reaction | es_ES |
dc.subject | aldmine | es_ES |
dc.subject | antifungal activity | es_ES |
dc.title | Synthesis of Aminoalkyl Sclareolide Derivatives and Antifungal Activity Studies | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-05-26T13:21:10Z | |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1420-3049/28/10/4067 | es_ES |
dc.identifier.doi | 10.3390/molecules28104067 | |
dc.departamentoes | Química orgánica I | |
dc.departamentoeu | Kimika organikoa I |
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Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).