Method Based on Ultrafiltration to Obtain a Plasma Rich in Platelet and Plasma Growth Factors
dc.contributor.author | Mercader Ruiz, Jon | |
dc.contributor.author | Beitia, Maider | |
dc.contributor.author | Delgado, Diego | |
dc.contributor.author | Sánchez, Pello | |
dc.contributor.author | Guadilla, Jorge | |
dc.contributor.author | Pérez de Arrilucea, Cristina | |
dc.contributor.author | Benito López, Fernando ![]() | |
dc.contributor.author | Basabe Desmonts, Lourdes ![]() | |
dc.contributor.author | Sánchez, Mikel | |
dc.date.accessioned | 2023-10-02T17:06:30Z | |
dc.date.available | 2023-10-02T17:06:30Z | |
dc.date.issued | 2023-09-13 | |
dc.identifier.citation | Journal of Clinical Medicine 12(18) : (2023) // Article ID 5941 | es_ES |
dc.identifier.issn | 2077-0383 | |
dc.identifier.uri | http://hdl.handle.net/10810/62727 | |
dc.description.abstract | Platelet-Rich Plasma (PRP) is an autologous biological product which, due to its regenerative capacity, is currently used in different fields of medicine. This biological treatment has proven to be effective in numerous research studies due to its high content of growth factors released by platelets. However, the current systems used to obtain PRP do not enrich the growth factors and cytokines outside platelets. Considering this, the present work aims to develop a new technique by which all the biomolecules present in plasma are enriched. Thus, a new method based on ultrafiltration has been developed for the obtaining of the novel PRP. By this method, ultrafiltration of the plasma water is carried out using a 3KDa filtering unit. The results showed that the technique was able to concentrate extraplatelet factors, such as IGF-1 and HGF, in contrast with conventional plasmas. Thus, the cultured cells responded with increased viability to this new PRP. These results could provide a new approach to the treatment of injuries requiring regenerative medicine, potentially improving the outcomes of the conventional PRPs. | es_ES |
dc.description.sponsorship | This research was funded by “Ministerio de Ciencia y Educación de España” under the grant PID2020-120313GB-I00/AIE/10.13039/501100011033, FEDER “una manera de hacer Europa”, and Gobierno Vasco Dpto. de Educación for the consolidation of the research groups (IT1633-22). Important to mention the founding support given to J. Mercader Ruiz by the UPV/EHU PIF Industrial “Ayudas para la formación de personal investigador en colaboración con instituciones y empresas” (reference PIFIND19/03) and to M. Beitia for the Torres Quevedo program grant (reference PTQ- 3122019-010386) of the Spanish Ministerio de Economía y Competitividad. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | platelet-rich plasma | es_ES |
dc.subject | hydrogel | es_ES |
dc.subject | water filtration | es_ES |
dc.subject | platelets | es_ES |
dc.subject | biomolecules | es_ES |
dc.subject | growth factors | es_ES |
dc.title | Method Based on Ultrafiltration to Obtain a Plasma Rich in Platelet and Plasma Growth Factors | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-09-27T12:36:26Z | |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2077-0383/12/18/5941 | es_ES |
dc.identifier.doi | 10.3390/jcm12185941 | |
dc.departamentoes | Química analítica | |
dc.departamentoes | Zoología y biología celular animal | |
dc.departamentoeu | Kimika analitikoa | |
dc.departamentoeu | Zoologia eta animalia zelulen biologia |
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Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).