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dc.contributor.authorBarbolla Cuadrado, Iratxe
dc.contributor.authorSotomayor Anduiza, María Nuria
dc.contributor.authorLete Expósito, María Esther
dc.date.accessioned2023-11-20T12:13:43Z
dc.date.available2023-11-20T12:13:43Z
dc.date.issued2019-07-29
dc.identifier.citationThe Journal of Organic Chemistry 84(16) : 10183-10196(2019)es_ES
dc.identifier.issn0022-3263
dc.identifier.issn1520-6904
dc.identifier.urihttp://hdl.handle.net/10810/63061
dc.description.abstractA convergent route to pyrrolo[1,2-b]isoquinolines with a quaternary center at C-10 has been developed, that implies a sequential Pd(0)-catalyzed carbopalladation followed by cross-coupling reaction with boronic acids. The adequate catalytic system and experimental conditions, with and without the use of phosphane ligands, have been selected to control the chemoselectivity of the process, allowing a 6-exo-carbopalladation to generate a quaternary center, and avoiding a direct Suzuki coupling. A variety of electron rich and electron deficient arylboronic acids can be used providing an efficient route to substituted pyrrolo[1,2-b]isoquinolines in moderate to good yields (up to 94%, 22 examples).es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad (CTQ2016-74881-P) // Gobierno Vasco (IT1045-16)es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/CTQ2016-74881-Pes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectpalladiumes_ES
dc.subjectSuzuki reactiones_ES
dc.subjectcascade reactionses_ES
dc.subjectalkaloidses_ES
dc.titleCarbopalladation/Suzuki Coupling Cascade for the Generation of Quaternary Centers. Access to Pyrrolo[1,2-b]isoquinolineses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2019, American Chemical Societyes_ES
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acs.joc.9b01357es_ES
dc.relation.publisherversionhttps://doi.org/10.1021/acs.joc.9b01357es_ES
dc.identifier.doi10.1021/acs.joc.9b01357
dc.departamentoesQuímica orgánica IIes_ES
dc.departamentoeuKimika organikoa IIes_ES


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