dc.contributor.author | Santiago Alvarez, Carlos | |
dc.contributor.author | Jiménez de Aberásturi González, Xabier | |
dc.contributor.author | Leicea, Eztizen | |
dc.contributor.author | Lete, Marta G. | |
dc.contributor.author | Sotomayor Anduiza, María Nuria | |
dc.contributor.author | Lete Expósito, María Esther | |
dc.date.accessioned | 2023-11-23T12:20:42Z | |
dc.date.available | 2023-11-23T12:20:42Z | |
dc.date.issued | 2021-12-22 | |
dc.identifier.citation | Organic & Biomolecular Chemistry 20 : 852-861(2022) | es_ES |
dc.identifier.issn | 1477-0520 | |
dc.identifier.issn | 1477-0539 | |
dc.identifier.uri | http://hdl.handle.net/10810/63125 | |
dc.description.abstract | The use of MW allows the efficient palladium(II)-catalysed C-3 acylation of thiophenes with aldehydes via C(sp2)-H activation for the synthesis of (cyclo)alkyl/aryl thienyl ketones (43 examples). Compared to standard thermal conditions, the use of MW reduces the reaction time (15 to 30 min vs. 1 to 3 hours), leading to improved yields of the ketones (up to 92%). Control of positional selectivity is achieved by 2-pyridinyl and 2-pyrimidyl ortho-directing groups at C-2 of the thiophene scaffold. To show the synthetic applicability, selected ketones were subjected to further transformations, including intramolecular
reactions to directly embed the directing-group in the core-structure of the new molecule | es_ES |
dc.description.sponsorship | Ministerio de Ciencia e Innovación (PID2019-104148GB-I00) / Gobierno Vasco (IT1045-16) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-104148GB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | palladium | es_ES |
dc.subject | C-H activation | es_ES |
dc.subject | acylation | es_ES |
dc.subject | microwave | es_ES |
dc.title | Microwave-assisted Palladium catalysed C-H acylation with aldehydes. Synthesis and diversification of 3-acylthiophenes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022, The Royal Society of Chemistry | es_ES |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2022/OB/D1OB02176A | es_ES |
dc.relation.publisherversion | https://doi.org/10.1039/D1OB02176A | es_ES |
dc.identifier.doi | 10.1039/D1OB02176a | |
dc.departamentoes | Química Orgánica e Inorgánica | es_ES |
dc.departamentoeu | Kimika Organikoa eta Ez-Organikoa | es_ES |