dc.contributor.author | Gutiérrez Camino, Ángela | |
dc.contributor.author | López López, Elixabet | |
dc.contributor.author | Martín Guerrero, Idoia | |
dc.contributor.author | Piñán, María Ángeles | |
dc.contributor.author | García Miguel, Purificación | |
dc.contributor.author | Sánchez Toledo, José | |
dc.contributor.author | Carbone Bañeres, Ana | |
dc.contributor.author | Uriz, José Javier | |
dc.contributor.author | Navajas Gutiérrez, Aurora | |
dc.contributor.author | García-Orad Carles, África | |
dc.date.accessioned | 2024-02-02T19:02:19Z | |
dc.date.available | 2024-02-02T19:02:19Z | |
dc.date.issued | 2014-03-11 | |
dc.identifier.citation | Pediatric Research 75(6) : 767-773 (2014) | es_ES |
dc.identifier.issn | 0031-3998 | |
dc.identifier.issn | 1530-0447 | |
dc.identifier.uri | http://hdl.handle.net/10810/64616 | |
dc.description.abstract | Background: Evidence for an inherited genetic risk for pediatric acute lymphoblastic leukemia has been provided in several studies. Most of them focused on coding regions. However, those regions represent only 1.5% of the entire genome. In acute lymphoblastic leukemia (ALL), it has been suggested that the expression of microRNAs (miRNAs) is dysregulated, which suggests that they may have a role in ALL risk. Changes in miRNA function may occur through single-nucleotide polymorphisms (SNPs). Therefore, the aim of this study was to evaluate whether polymorphisms in pre-miRNAs, and/or miRNA-processing genes, contribute to a predisposition for childhood ALL.
Methods: In this study, we analyzed 118 SNPs in pre-miRNAs and miRNA-processing genes in 213 B-cell ALL patients and 387 controls.
Results: We found 11 SNPs significantly associated with ALL susceptibility. These included three SNPs present in miRNA genes (miR-612, miR-499, and miR-449b) and eight SNPs present in six miRNA biogenesis pathway genes (TNRC6B, DROSHA, DGCR8, EIF2C1, CNOT1, and CNOT6). Among the 118 SNPs analyzed, rs12803915 in mir-612 and rs3746444 in mir-499 exhibited a more significant association, with a P value <0.01.
Conclusion: The results of this study indicate that SNP rs12803915 located in pre-mir-612, and SNP rs3746444 located in pre-mir-499, may represent novel markers of B-cell ALL susceptibility. | es_ES |
dc.description.sponsorship | A.G.-C. was supported by a predoctoral grant from the Gangoiti Barrera Foundation, Bilbao, Spain. E.L.-L. was supported by a predoctoral grant of the Basque Government and “Fellowship for recent doctors until their integration in postdoctoral programs” by the Investigation Vice-rector’s office of the University of Basque Country (UPV/EHU). This project was supported by Spanish Thematic Network of Cooperative Research in Cancer (RD/06/0020/0048), the Basque Government (IT661-13, S-PE12UN060), and UPV/EHU (UFI11/35). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.title | Noncoding RNA-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2014, International Pediatric Research Foundation, Inc. published by Springer | es_ES |
dc.relation.publisherversion | https://www.nature.com/articles/pr201443 | es_ES |
dc.identifier.doi | 10.1038/pr.2014.43 | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |