Transcriptomic profile reveals gender-specific molecular mechanisms driving multiple sclerosis progression
dc.contributor.author | Irizar, Haritz | |
dc.contributor.author | Muñoz Culla, Maider | |
dc.contributor.author | Sepúlveda, Lucía | |
dc.contributor.author | Sáenz Cuesta, Matías | |
dc.contributor.author | Prada, Alvaro | |
dc.contributor.author | Castillo Triviño, Tamara | |
dc.contributor.author | Zamora López, Gorka | |
dc.contributor.author | López de Munain Arregui, Adolfo José | |
dc.contributor.author | Olascoaga, Javier | |
dc.contributor.author | Otaegui Bichot, David | |
dc.date.accessioned | 2024-02-08T09:36:11Z | |
dc.date.available | 2024-02-08T09:36:11Z | |
dc.date.issued | 2014-02-28 | |
dc.identifier.citation | PLOS ONE 9(2) : (2014) // Article ID e90482 | es_ES |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10810/65053 | |
dc.description.abstract | Background: Although the most common clinical presentation of multiple sclerosis (MS) is the so called Relapsing-Remitting MS (RRMS), the molecular mechanisms responsible for its progression are currently unknown. To tackle this problem, a whole-genome gene expression analysis has been performed on RRMS patients. Results: The comparative analysis of the Affymetrix Human Gene 1.0 ST microarray data from peripheral blood leucocytes obtained from 25 patients in remission and relapse and 25 healthy subjects has revealed 174 genes altered in both remission and relapse, a high proportion of them showing what we have called "mirror pattern'': they are upregulated in remission and downregulated in relapse or vice versa. The coexpression analysis of these genes has shown that they are organized in three female-specific and one male-specific modules. Conclusions: The interpretation of the modules of the coexpression network suggests that Epstein-Barr virus (EBV) reactivation of B cells happens in MS relapses; however, qPCR expression data of the viral genes supports that hypothesis only in female patients, reinforcing the notion that different molecular processes drive disease progression in females and males. Besides, we propose that the "primed'' state showed by neutrophils in women is an endogenous control mechanism triggered to keep EBV reactivation under control through vitamin B12 physiology. Finally, our results also point towards an important sex-specific role of non-coding RNA in MS. | es_ES |
dc.description.sponsorship | This project has been supported by the Spanish Health Ministry (FIS project (PS09/02105) and the SAIOTEK program (SAIO11-PC11BN003 project) of the Basque Government. MMC and HI are supported by predoctoral grants from the Department of Education, University, and Research of the Basque Government. TCT is supported by a Río Hortega Grant from the Spanish Health Ministry. GZL is supported by the German Federal Ministry of Education and Research (Bernstein Center II, grant no. 01GQ1001A) and by the European Union Seventh Framework Programme FP7/2007-2013 under grant agreement n° PIEF-GA-2012-331800. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library Science | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | Epstein-Barr virus | es_ES |
dc.subject | b-cells | es_ES |
dc.subject | demyelination | es_ES |
dc.subject | gene expression | es_ES |
dc.subject | phenotype | es_ES |
dc.subject | multiple sclerosis | es_ES |
dc.subject | transcriptome | es_ES |
dc.subject | gender | es_ES |
dc.title | Transcriptomic profile reveals gender-specific molecular mechanisms driving multiple sclerosis progression | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2014 Irizar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.relation.publisherversion | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090482 | |
dc.identifier.doi | 10.1371/journal.pone.0090482 | |
dc.departamentoes | Procesos psicológicos básicos y su desarrollo | es_ES |
dc.departamentoeu | Oinarrizko psikologia prozesuak eta haien garapena | es_ES |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as © 2014 Irizar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.