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dc.contributor.authorMarcano Prieto, Lourdes
dc.contributor.authorOrue Goikuria, Iñaki ORCID
dc.contributor.authorGandia Aguado, David
dc.contributor.authorGandarias Albaina, Lucia ORCID
dc.contributor.authorWeigand, Markus
dc.contributor.authorAbrudan, Radu Marius
dc.contributor.authorGarcía Prieto, Ana
dc.contributor.authorGarcía Arribas, Alfredo
dc.contributor.authorMuela Blázquez, Alicia
dc.contributor.authorFernández Gubieda Ruiz, María Luisa
dc.contributor.authorValencia, Sergio
dc.date.accessioned2024-02-09T15:44:26Z
dc.date.available2024-02-09T15:44:26Z
dc.date.issued2022-04-06
dc.identifier.citationACS Nano 16 : 7398−7408 (2022)es_ES
dc.identifier.issn1936-0851
dc.identifier.issn1936-086X
dc.identifier.urihttp://hdl.handle.net/10810/65966
dc.description.abstractOver the past few years, the use of nanomagnets in biomedical applications has increased. Among others, magnetic nanostructures can be used as diagnostic and therapeutic agents in cardiovascular diseases, to locally destroy cancer cells, to deliver drugs at specific positions, and to guide (and track) stem cells to damaged body locations in regenerative medicine and tissue engineering. All these applications rely on the magnetic properties of the nanomagnets which are mostly determined by their magnetic anisotropy. Despite its importance, the magnetic anisotropy of the individual magnetic nanostructures is unknown. Currently available magnetic sensitive microscopic methods are either limited in spatial resolution or in magnetic field strength or, more relevant, do not allow one to measure magnetic signals of nanomagnets embedded in biological systems. Hence, the use of nanomagnets in biomedical applications must rely on mean values obtained after averaging samples containing thousands of dissimilar entities. Here we present a hybrid experimental/theoretical method capable of working out the magnetic anisotropy constant and the magnetic easy axis of individual magnetic nanostructures embedded in biological systems. The method combines scanning transmission X-ray microscopy using an axi-asymmetric magnetic field with theoretical simulations based on the Stoner−Wohlfarth model. The validity of the method is demonstrated by determining the magnetic anisotropy constant and magnetic easy axis direction of 15 intracellular magnetite nanoparticles (50 nm in size) biosynthesized inside a magnetotactic bacterium.es_ES
dc.description.sponsorshipL.M. acknowledges the financial support provided through a postdoctoral fellowship from the Basque Government (POS-2019-2-0017). Funding from the Spanish Government (grant PID2020-115704RB-C31 funded by MCIN/AEI/10.13039/501100011033) and from the Basque Government (projects IT-1245-19 and KK-2021/00040) is acknowledged. We acknowledge the technical and human support provided by SGIker (UPV/EHU). We thank the HZB for the allocation of synchrotron radiation beamtime and funding under the project CALIPSOplus (Grant Agreement 730872) from the EU Framework Programme for Research and Innovation HORIZON2020.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relationinfo:eu-repo/grantAgreement/MCIN/PID2020-115704RB-C31
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/730872
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectX-ray magnetic circular dichroismes_ES
dc.subjectscanning transmission X-ray microscopyes_ES
dc.subjectmagnetotactic bacteriaes_ES
dc.subjectMagnetovibrio blakemorei MV-1es_ES
dc.subjectnanomagnetses_ES
dc.subjectmagnetic nanoparticlees_ES
dc.subjectmagnetic anisotropyes_ES
dc.titleMagnetic Anisotropy of Individual Nanomagnets Embedded in Biological Systems Determined by Axi-asymmetric X‑ray Transmission Microscopyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2022 American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0.es_ES
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acsnano.1c09559?ref=pdfes_ES
dc.identifier.doi10.1021/acsnano.1c09559
dc.contributor.funderEuropean Commission
dc.departamentoesFísica Aplicada
dc.departamentoeuFisika Aplikatua


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© 2022 American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0.
Except where otherwise noted, this item's license is described as © 2022 American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0.